Calculate serum osmolality
[ 2 x serum Na in mEq/L + ( plasma glucose in mg/dL / 18 ) + ( BUN in mg/dL / 2.8 ) ]
Mechanism of action of sulfonylureas.
Bind and close ATP-sensitive potassium channels
Test of choice to detect latent TB in patients who have received BCG vaccine
Interferon Gamma Release Assay (IGRA) / Quantiferon GOLD / T spot
Premature CAD in males is when CAD develops less than this age
<55 yo in M; <65 in F
Thiazide diuretics may not be effective if eGFR is less than this
eGRF <30 mL/min/1.73 m2
MEN (Multiple Endocrine Neoplasia) 2A comprises of this.
Thyroid medullary carcinoma, pheochromocytoma, parathyroid tumors
Name 2 scenarios where we treat asymptomatic bacteriuria
Pregnancy, renal transplant recipients within the 1st month, patients undergoing invasive renal/bladder procedure
Name 2 physiologic maneuvers that can increase murmurs from hypertrophic obstructive cardiomyopathy
Handgrip, standing, Valsalva
First line antihypertensive agent/s in adults s/p kidney transplants
Dihydropyridine CCBs / ARBs
eGFR range where Metformin is absolutely contraindicated for treatment of T2DM
eGRF <30 mL/min/1.73 m2
Name atleast 2 findings in an exudative pleural fluid that would make a parapneumonic effusion complicated
Positive gram stain/culture, pH<7.2, glucose <40 mg/dL, LDH >1000 IU/L
Mechanism of action of PCSK9 inhibitors (Alirocumab and Evolocumab) in lowering LDL
Monoclonal antibodies that bind to PCSK9, inhibiting degradation of LDL-R, leading to higher hepatic LDL-R expression and uptake of LDL
Metabolic alkalosis, hypercalcemia and acute kidney injury after ingestion of calcium carbonate is termed this
Milk-Alkali Syndrome
Adrenal insufficiency is diagnosed when serum cortisol is below this level after 30 to 60 minutes of high-dose (250 mcg IV) ACTH stimulation
<18 mcg/dL
Antiobiotic regimen in a patient with fulminant clostridium difficile colitis WITHOUT ileus
Vancomycin 500mg orally/NGT every 6 hours AND Metronidazole 500mg IV every 8 hours for 10-14 days
Target heart rate and SBP for acute management of this condition
HR <60bpm and SBP within 100-120 mmHg
Balkan endemic nephropathy is associated with this malignancy
Transitional (urothelial) cell cancer
Severe and prolonged hypocalcemia that occurs after parathyroidectomy is termed this
Hungry Bone Syndrome
COV-BARRIER study in COVID-19 was done using this investigational agent/drug
Baricitinib (JAK1/2 Inhibitor)
Criteria for cardiac resynchronization therapy
Symptomatic heart failure (NYHA II-IV) with EF </= 35% despite optimal medical therapy for 3 months, in sinus rhythm with LBBB & QRS>150msec