BCR
Two types of light chains.
What are lambda and kappa?
These polypeptide chains that make up the TCR.
What are the alpha and beta chains?
Presents antigens from autophagy.
What is MHC class II?
Enzymes that drive gene rearrangement.
What are RAG-1 and RAG-2?
What are TNF, IL-1beta and IL-6.
Fragment important for membrane binding.
What is the Fc fragment?
These are recognized by the TCR.
What are antigen and MHC molecules?
Process by which dendritic cells activate CD8 T cells in the absence of infection.
What is cross presentation?
Signals that determine locations of somatic recombination.
The class I MHC molecules in humans.
What are HLA-A, HLA-B and HLA-C?
These regions from the heavy and light chain combine to determine antigen specificity.
What are hypervariable regions?
These molecules help stabilize interactions between TCR and peptide:MHC class II.
What is CD4?
Protein that generates peptide fragments in the cytosol for antigen presentation.
What is the proteasome?
Segments required for TCR beta formation.
What are the variable, diversity and joining segments?
Source of acute phase proteins.
What is the liver?
Bonds that maintain BCR structure.
What are disulfide bonds?
Contributes to T cell signalling.
What is CD3?
Location generation of peptide fragments for MHC class II.
What is the endosome?
These contribute to the diversity of MHC molecules.
What are polymorphism and polygeny?
Isotypes that form dimers and multimers.
What are IgA and IgM?
Isotype with high affinity with mast cells and basophils.
What is IgE?
These types of antigens are recognized by TCR but not BCR?
What are antigens buried in the native protein structure?
These proteins transport peptides form the cytoplasm into the ER.
What are TAP1 and TAP2?
Name of MHC genes in humans.
What is human leukocyte antigen (HLA)?
Required for killing of microbes after phagocytosis.