Immunology
This leukocyte is known to produce antibodies
What are B cells?
This technique uses a heat-stable polymerase to amplify specific DNA sequences
What is PCR?
The traits defined as the acquired functional capababilities that allow normal cells to become cancer cells (Weinburg)
What are the Hallmarks of Cancer?
Our research grandmother (name of Dr. J's PI)
Who is Dr. Wei-Zen Wei?
These immune cells are commonly referenced as the immune system's "clean-up" crew.
What are macrophages?
When using a centrifuge, you must always do this to the rotor to prevent damage or "walking" of the machine.
What is balancing?
These "gain-of-function" genes have the potential to cause cancer when they are overexpressed or mutated.
What are oncogenes?
Name 3 background strains from the DO model?
What are A/J, C57BL/6J, 129S1/SvImJ, NOD/ShiLtJ, NZO/HlLtJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ?
Granulocyte known as the "first responder" in the immune system.
What are Neutrophils?
This method uses a laser to analyze the physical and chemical characteristics of particles in a fluid as they pass through a beam
What is Flow Cytometry?
Monoclonal antibody named Trastuzumab (Herceptin), specifically targets this receptor
What is HER2?
The location of the lab's SDS sheets
Where is the Google Drive?
Lineage marker expressed on ALL immune cells
What is CD45?
A Western Blot quantifies what molecular structure?
What are proteins?
This tumor suppressor gene is mutated in over 50% of all cancers?
What is p53
The drug candidate is actively being used in the lab is _______-______ and is clinically known as what drug class
What is Trastzumab-Deruxtucan and an Antibody-Drug Conjugate (ADC)?
The specific part of an APC that presents antigens
What is the MHC?
The method used to determine the exact molecular weight of a protein or chemical compound with high precision
What is Mass Spec
This describes cancer cells' preference for glycolysis over oxidative phosphorylation, even in the presence of oxygen. (PET Scan)
What is the Warburg Effect?
In metastases, cancerous cells enter the bloodstream/lymph via this process
What is intravasation?