Mechanism of Action
This class of medications works by blocking the reuptake of serotonin and norepinephrine
What is SNRIs?
Fluoxetine is a potent inhibitor of this cytochrome P450 enzyme, which is responsible for metabolizing many psychotropics including aripiprazole and risperidone.
What is CYP2D6?
In Bipolar II, hypomanic episodes must last at least this many consecutive days
What is 4 days?
This antipsychotic is most associated with prolactin elevation
What is Risperidone ?
This medication is a partial agonist at 5-HT1A receptor and it has no abuse potential.
What is Buspirone?
Carbamazepine is a potent inducer of this enzyme, which metabolizes oral contraceptives, leading to contraceptive failure.
What is CYP3A4?
DSM-5 requires symptoms of PTSD to persist beyond this minimum duration to distinguish it from Acute Stress Disorder?
What is 1 month?
This medication we use very often can cause alopecia
What is Depakote?
This medication inhibits inositol monophosphatase and modulates GSK-3B signaling. Not completely understood
What is Lithium?
Aripiprazole is metabolized by both?
What is CYP2D6 and CYP3A4?
Insomnia disorder in DSM-5 requires symptoms at least 3 nights a week for this minimum duration?
What is 3 months ?
This medication prescribed to treat an antipsychotic side effect can paradoxically worsen tardive dyskinesia while masking its symptoms
Benztropine (Cogentin)
Naltrexone blocks the rewarding effects of alcohol in the ventral tegmental area and nucleus accumbens. It is a competitive antagonist at what 3 receptors?
What is Mu, Delta, kappa opioid receptors ?
This antipsychotic is a major CYP1A2 substrate, requires dose reductions by half when combined when Fluvoxamine (luvox)
What is Zyprexa (Olanzapine)?
Does Narcolepsy in DSM-5 require a specific lab finding?
yes and what is CSF hypocretin-1 (orexin) deficiency?
This medication can cause QTc prolongation severe enough to cause torsade's de pointes, prompting FDA safety communication and required EKG monitoring.
What is Methadone?
Cyproheptadine, antidote for serotonin syndrome, works by antagonizing these two receptors?
What is 5-HT2A and H1 receptors ?
This antipsychotic is unique because it is largely free of CYP-mediated drug interactions. It is metabolized by aldehyde oxidase.
What is Geodon (Ziprasidone)?
DSM-5 eliminated the requirement for this physiological finding in Anorexia Nervosa that was mandatory in DSM-4?
What is amenorrhea?
This medication can cause propylene glycol toxicity when given IV for prolonged periods of time
What is Ativan (Lorazapam) ?