The Logic of Disease
Pathways of Infection
Inflammatory Mediators
The WBC Brigade
Advanced Microbes
100

This term refers to the fundamental cause of a disease, which may be biological, physical, or chemical in nature.

Etiology

100

This is the step in the "chain of infection" where the pathogen hitches a ride, such as via contaminated food or an insect bite.

Mode of Transmission

100

This watery, low-protein exudate is typically found in mild injuries, such as the fluid within a skin blister.

Serous exudate

100

These are the very first white blood cells to arrive at an injury site, usually appearing within 90 minutes.

Neutrophils

100

These are the smallest infectious agents; they lack a nucleus and must live inside a host cell to replicate.

Viruses

200

This type of reasoning starts with a general premise and moves to a specific conclusion; it is concerned with the rules for determining if an argument is valid.

Deductive Reasoning

200

This term refers to an inanimate object, such as a doorknob or a shared toy, that can carry and spread infectious organisms.

Fomite

200

These chemical mediators are slower-acting than histamine and are primarily responsible for the broncho-constriction seen in asthma.

Leukotrienes

200

An increase in this specific white blood cell count is often a hallmark of allergic reactions or parasitic infestations.

Eosinophils

200

These unusual infectious agents are actually "misfolded proteins" that cause neurodegenerative diseases like Mad Cow Disease.

Prions

300

This term describes the consistency of an observation; it is the extent to which a measurement, if repeated, gives the same result.

Reliability

300

This type of transmission occurs when an infectious agent is carried by a living creature, such as a mosquito or a tick.

Vectorborne transmission

300

This plasma protein system, once activated by an antigen-antibody reaction, creates a "membrane attack complex" to destroy bacteria.

Complement system

300

This term refers to the "rolling" and "sticking" of white blood cells along the inner lining of a blood vessel before they exit into the tissue.

Margination and Adhesion

300

This term describes the overall "potency" or disease-producing power of a microorganism.

Virulence

400

This type of reasoning moves from specific observations to general conclusions and is based on "probability theory."

Inductive reasoning

400

These are the two general ways a pathogen can enter a new host, such as through the respiratory tract or a break in the skin.

Portals of entry

400

This stage of the acute inflammatory response is characterized by the movement of fluid out of the capillaries and into the tissue spaces, causing swelling.

Vascular stage

400

This value is calculated by multiplying the percentage of a specific cell type by the total white blood cell count.

Absolute count

400

This group of parasites includes roundworms and tapeworms, which are typically transmitted through contaminated soil or food

Helminths

500

This term refers to the number of new cases of a disease arising in a population during a specified period of time.

Incidence

500

his term describes the ability of a host's body to resist a pathogen; it is the opposite of being susceptible.

Immunity (Resistance)

500

This specific cytokine is released by macrophages and serves as a major mediator of the acute phase response, inducing both fever and the "shift to the left."

Tumor Necrosis Factor-alpha (TNF-α)

500

This is the term for the process where white blood cells move toward the site of injury by following a chemical gradient or "scent."

Chemotaxis

500

These microbes are unique because they possess both a cell wall and a nucleus, but unlike plants, they do not perform photosynthesis.

Fungi

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