Clinical Clues
Differential
What's next?
Treatment
Don't get fooled
100

A patient is pale, cool, diaphoretic and has delayed capillary refill. What broad physiologic problem should you immediately consider?

Poor perfusion/shock.

100

Name four causes of altered mental status.

Hypoglycemia

Stroke

Seizure

Toxicologic

Sepsis

Hypoxia

Metabolic

Electrolyte

100

Dyspneic patient. What is your immediate assessment priority?

Airway/breathing/oxygenation/ventilation.

100

What should guide oxygen therapy?

Patient assessment and oxygenation/ventilation status, consistent with local protocol.

100

Patient says, "I have anxiety." Should you stop looking for a medical cause?

NO!

200

A dyspneic patient is speaking in one-word responses and becoming increasingly fatigued. What does this suggest?

Severe respiratory distress with possible impending ventilatory failure.

200

Name four causes of dyspnea.

CHF

COPD/asthma

Pneumonia

PE

Pneumothorax

ACS

Metabolic

200

Altered patient. What bedside measurement should be obtained early?

Blood glucose.

200

Why do we reassess after medication?

To evaluate effectiveness and adverse effects.

200

True/ False: Normal vital signs rule out serious illness.

False. 

300

Why isn't one abnormal vital sign enough to diagnose a patient?

Vital signs must be interpreted within the entire clinical picture and trended.

300

Abdominal pain + shock. Give three diagnoses you absolutely don't want to miss.

AAA

GI hemorrhage

Sepsis

ACS

Ectopic pregnancy when applicable

300

Concerning chest discomfort. What diagnostic tool should be considered early?

12-lead ECG.

300

What's dangerous about treating solely because a patient has a familiar diagnosis?

The diagnosis may be wrong, or another condition may be present.

300

True/False: Your Patient improves after glucose; therefore, hypoglycemia was the only problem.

False.

400

Chest discomfort + hypotension + altered mental status + diaphoresis. What should drive your immediate priorities?

Recognition and treatment of life threats/poor perfusion while continuing diagnostic assessment.

400

Why shouldn't you anchor on the first plausible diagnosis?

Because new evidence may contradict the initial hypothesis.

400

Patient deteriorates after an intervention. What should you do before simply repeating the intervention?

Reassess and determine why the patient isn't responding.

400

Hypotensive patient with suspected cardiogenic pulmonary edema. What should guide treatment?

Assessment of airway, breathing and perfusion; hemodynamics; local protocol; appropriate medical control.

400

True/False: Your Patient has a history of CHF and is short of breath. Therefore, today's problem is CHF.

False.

500

A patient initially appears stable but becomes altered and hypotensive. What clinical judgment principle is most important?

Reassessment and revision of the clinical impression as the patient's condition changes.

500

Fever + tachycardia + hypotension + altered mental status. Give two competing hypotheses and one finding that could help distinguish them.

Accept reasonable answers with appropriate rationale.

500

Patient is in shock and the cause is unclear. What is the safest cognitive approach?

Treat immediate threats, maintain a broad differential, gather targeted information, reassess and revise.


500

Can treatment response help with diagnosis?

Yes, it provides additional clinical information—but response alone does not prove the diagnosis.

500

What is premature closure?

Stopping the diagnostic search after finding a plausible explanation despite potentially contradictory evidence.

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