Adverse effects
What is the main adverse effect associated with vancomycin?
nephrotoxicity
Which drug class should you utilize Time>MIC for dose optimization
PCNS, cephalosporins, macrolides, clindamycin
daptomycin
What is MIC?
The lowest concentration of an antimicrobial agent that inhibits growth of microorganisms
Which antibiotic drug class has the following adverse effects: QT prolongation, tendon rupture, aortic rupture, peripheral neuropathy
fluoroquinolones
Name a drug class with cidal activity
Which cephalosporin covers MRSA?
ceftaroline
Should you use clindamycin below or above the diaphragm?
Above the diaphragm
Name an adverse effect of linezolid
thrombocytopenia, optic neuritis, or peripheral neuropathy
What is the new AUC/MIC ration goal for serious MRSA infections?
400-600
What drug should you use for vancomycin resistant MRSA?
daptomycin
Name one antibiotic that does not need renal adjustments?
nafcillin, oxacillin, ceftriaxone, clindamycin, azithromycin, erythromycin, moxifloxacin, doxycycline, tigecycline, or rifampin