Oncology Models
What was the first single knockout mouse with an ultra immunodeficient phenotype?
B-NDG (NOD.CB17-Prkdc scid tm1/BcgenHsd
What overall research could benefit from the B-NDG
Oncology research
Which cells are a part of the immune system that focuses on specific foreign particles. Rather than generically attack any antigens, They circulate until they encounter their specific antigen. As such, these cells play a critical part in immunity to foreign substances.
T-Cells
Trade shows such as Life Sciences or scientific solutions.
Which non rodent animals are used in Oncology research?
NHP also farm animals, birds, and fish. There can be others in smaller percentages
Which B-NDG model has a deficiency in cytokine signaling?
B-NDG hiL15 Mice (hiL15)
What can you use the B-NDG for in Cancer cell research?
Cancer cell transplantation
Which cells are a type of lymphocyte that are responsible for the humoral immunity component of the adaptive immune system. These white blood cells produce antibodies, which play a key part in immunity. These cells contains a single round nucleus.
B Cells
Any of the following
Mike, Andrew, Aaron, Travis, Roxanne, other AMs etc.
What is the #1 model used in oncology research?
Rodents
Which B-NDG model in in the MHC class I deficiency?
B-NDG B2m Double Knockout Plus mice (B2m)
[Drug efficacy evaluation]
What type of reserch creates new vaccines?
Immunology
What is a type of immune cell that has granules (small particles) with enzymes that can kill tumor cells or cells infected with a virus. It is is a type of white blood cell.
Natural killer cells
What is another option to share this model with your clients?
Webinars, Showpad, national and regional AALAS events etc.
What are any model variances to consider in Oncology model selction
Haired vs hairless
Immunodeficient vs immunocompetent
Spontaneous vs inducible
Etc
Who is the competetor of the model NCG that competes with the BNDG ?
CRL
What type of research keeps populations safe?
Infectious disease
Is this model deficient or not deficient in cytokine signaling?
There is a deficiency in cytokine signaling.
Are there any tools to assist in allowing our clients to validate these models?
Sampling if approved.
Is the suseptibility to growing desited tumors a benefit of the B-NDG?
Yes
Who is the competetor to the BNDG with the model NSG?
Jackson Labs
What are the key applications of this model?
Humanization
What is the traditional model that this model demonstrated a decreased leakiness?
SCID
Who did Envigo license this model from?
Biocytogen in 2019
What can impact an oncology study other than the model selected?
Diet