Name the Protein
This is a marker indicating a protein for degradation via proteases
What is Ubiquitin?
Maple Syrup Urine Disease is characterized by the inability to break down certain amino acids, caused by a deficiency in this enzyme.
What is branched chain alpha-keto acid dehydrogenase?
Blue ate a death cap mushroom. RIP Blue. This caused his death.
What is Alpha-Amantadine? --> Inhibition of RNA Polymerase II
This recognizes the promoter sequence on prokaryotic DNA and is made up of these two components
What is Holoenzyme and Core enzyme and Sigma Factor?
This drug targets prokaryotic DNA gyrase also known as this.
What is Fluoroquinolone and Type II topoisomerase?
In the clinic, doctors can use this to differentiate exogenous insulin from synthesized insulin, as it has 10x the half-life of insulin.
What is C-Peptide?
While other doctors may suspect child abuse, you know that your 5 year old patient's bone fracture is caused by a mutation that does this and you can tell by this very telling clinical presentation.
What is glycine substitution and blue sclerae?
Lyla Drank a puddle of Propylene Glycol. You would expect her blood to be this pH.
What is less than 7.35?
This allows for RNA Polymerase to have more access to DNA
What is Acetylation of H1?
This protein acts a a supportive scaffold to help maintain integrity of the cell membrane
What is Spectrin?
Proteins that assist other proteins to fold correctly
What are Chaperones?
This disease AND mutation are charaterized by the inability to degrade Very Long Chain Fatty Acids (VLCFA) and synthesize myelin
What are Zellweger Syndrome and PEX?
Ut oh Kiwi ate some limes. At least she can no longer get Scurvy since Vitamin C is a cofactor for an an enzyme that does this.
What is hydroxylation of proline and lysine?
The energy required for formation of the peptide bond by peptidyltransferase comes from this and requires this
What is charged tRNA and GTP
This is a mechanism of reducing gene expression by repressing translation or increasing degradation of mRNA
What is RNA interference?
This is a rod shaped protein important for anchoring the cell to the extracellular matrix.
What is Dystrophin?
Your patient may look like he can dunk due to the size of his calves, but unfortunately it may be due to this genetic condition that causes a truncation of a certain protein.
What is Becker Muscular Dystrophy?
Arnold ate an Alien DNA-altering substance causing an autosomal recessive mutation in the dynein arms of his cells, so he now is infertile and has this disease.
What is Primary Ciliary Dyskinesia and Kartagener Syndrome?
This enzyme does it all. It has proofreading activity of DNA, can elongate the leading strand, and can elongate the lagging strand
This intermediate filament can be found surrounding smooth, cardiac, and skeletal muscle
What is Desmin?
This peptide sequence within a protein marks a protein for rapid degradation
What is PEST (Proline, Glutamate, Serine, and Threonine)?
Your patient drank the green juice from Lucky B's. Your patient now has these three diseases that cause deficiency in: Arylsulfatase A , Hexosaminidase A, and Beta-galactocerebrosidase
What are Metachromatic Leukodystrophy, Tay-Sachs, and Krabbe Disease?
Ut Oh. Blue ate A TON of this antibiotic. If he had eaten these other 3 in the same class, he would be fine. But now his mitochondrial protein synthesis is out of whack.
What is Chlramphenicol and Streptomycin, Erythromycin (Macrolide), Tetracycline?
Telomerase contains its own this. Which allows it to create repeating DNA fragments.
What is reverse transcriptase?
This intracellular messenger that requires Protein Kinase A is stimulated by this hormone to increase gluconeogenesis
What is CREB and Glucagon?