Pedigree/Inheritance
Probability of Inheritance
Allele/Gene Interactions
100
What is the most likely genotype of individual II-2?
Assume the tracked trait is autosomal recessive
Heterozygous (carrier)
100
Consider a cross between a homozygous dominant (AA) individual and a heterozygous (Aa) individual. What is the probability an offspring will be homozygous dominant?
50%
100
You perform a complimentation test on two recessive mutations and discover the mutations do NOT compliment each other. Are the mutations most likely located on the same gene or different genes?
The same gene
200
What is the most likely mode of inheritance for this single gene trait being tracked in this pedigree?
Autosomal recessive
200
Gene Ay is a recessive lethal allele. Two heterozygous parents are crossed, what is the resulting ratio of phenotypes of the offspring?
2:1 ratio
(The homozygous recessive Ay/Ay offspring will die as embryos)
300
Given this pedigree is tracking an autosomal dominant trait, what must be the genotype of individual III-4?
Heterozygous (carrier)
300
In Hyraxes, the following alleles of an autosomal gene affecting coat color are listed in decending order of dominance:
B (brown) > bg (green) > bb (black) > ba (albino)
A cross between a green male and a brown female produced the following progeny:
10 brown, 5 green, 5 black
What is a possible genotype of the green male parent?
Either of the following:
bg / bb
or
bg / ba
400
This pedigree tracks an x-linked recessive single gene trait. What is the probability individual III-4 is a carrier for the trait?
50% chance of III-4 being a carrier
400
Use this regulatory pathway.
A scientist creates a Gene B knockout, a Gene C knockout, and a double Gene B and Gene C knockout.
The double knockout (BkoCko) has the same phenotype as the Gene B knockout.
Which gene is epistatic?
Gene C is epistatic to Gene B
500
Given that this pedigree is tracking an X-linked recessive trait, if individual IV-3 mates with an affected female, what proportion of the female offspring will be carriers?
100% of female offspring will be carriers
IV-3 is XAY, mates with an affected female XaXa
So all daughters will be XAXa (carrier)
500
The following regulatory pathway is involved in cell proliferation (division). One parent is homozygous null for Gene D, the other parents is homozygous wildtype for Gene D.
Assume both parents are homozygous wild type for all genes except Gene D. The Gene D wild-type allele is dominant to the null allele.
What will be the phenotype (increased/decreased proliferation) of the offspring of these parents?
The offspring will show increased cell proliferation