Hemostasis
Define Fibrinolysis
Process of dissolving the clot
What is the reference range for PT/INR
10-13 Seconds
What specimen would you collect a coagulation test on?
-3.2% sodium citrate
9:1 ratio
Classes of Immunoglobulins
IgG, IgM, IgA, IgD, IgE
What are the 3 general health requirements to donate blood
Weight 110 lbs
Age 16 years
Temp < 99.5 degs F
BP <180/100
Hgb >11g/dL or 33% Hct
Vitamin K dependent factors
Factors: II VII IX and X
Name 2 inherited hemostasis disorders
Hemophilia A
Hemophilia B
4 coagulation instrument technologies
visual
mechanical
magnetic
optical
What are the primary lymphad organs
Bone marrow, Thymus
Name the 4 major blood groups
A, B, AB, O
What are the factors involved in the extrinsic pathway?
Vessel injury-> Tissue Factor + VII -> VIIa
X->Xa
What is the major use of aPTT
CPDA
Describe the primary & secondary immune responses
IgM-->IgG
D, C, c, E, e
What are the 3 coagulation pathways
3 conditions the D-Dimer test can aid in evaluation and diagnosis
DIC DVT PE
What are the donor blood components
RBCs, Plts, FFP
Which immunoglobulin has the ability to cross the placenta
IgG
What is the patients blood type
anti-A | anti-B | anti-D | a, cells | b cells
0 0 4+ 4+ 4+
Explain primary hemostasis which is the process of forming the primary platelet plug
Exposed to collagen->plt adhesion->plt aggregation->release rxn->plt plug forms
A farmer, Mr. Hawkins was turning his tractor at the end of a row on an incline. The tractor flipped over, and Mr. Hawkins was pinned under the machine. Fortunately, a friend was nearby and summoned help. In the ED his symptoms were pain, bleeding & signs of blood clots. What is a possible diagnosis & what test would you order?
DIC, D-Dimer, PT aPTT, Fibrinogen, plt Count
What type (method) of test is considered the gold standard in blood bank?
Tube testing
2 types of specific immunity & cell(s) involved
humoral immunity---->B cells
cell-mediated immunity--->T cells
Describe Hemolytic disease of the Newborn
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