Mr. Rogers' Neighborhood
This additional step should be considered during physical exam when assessing for Marchiafava Bignami
"Wave hello with your left hand!" This can assess for left hand apraxia, a symptom that can occur with the demyelination of the corpus callosum
These are the clinical and imaging clues included within the formal diagnostic criteria for Marchiafava-Bignami disease
Trick question! There is no formal diagnostic criteria for Marchiafava-Bignami disease.
This is a key difference between Korsakoff's Disease and Marchiafava-Bignami disease
Korsakoff's Disease is generally not reversible, while Marchiafava-Bignami is reversible with early diagnosis and early thiamine supplementation
This MRI finding is a pathognomonic sign for Marchiafava-Bignami disease
Demyelination and necrosis of the corpus callosum
In antemortum patients with Marchiafava-Bignami, this can be seen in biopsy of the corpus callosum
Myelin debris inside the cytoplasm of macrophages