Chapter 12
The more reliable elimination method.
What is E2?
The most reactive carboxylic acid derivative.
The least reactive carboxylic acid derivative.
What is carboxylate?
The best leaving group.
What is chloride ion?
The formation of a hemiacetal.
What is the acid-catalyzed reaction between an alcohol and ketone/aldehyde?
The most stable alkene.
What is the most conjugated and substituted alkene?
The bond that breaks first in the acyl substitution reactions.
What is carbonyl pi bond?
The worst leaving group.
What is amide ion?
The leaving group of an acetal formation.
What is water?
This liquid is required for the oxidation of an aldehyde to carboxylic acid.
What is water?
It performs nucleophilic attacks to form new bonds.
What are atoms with lone pairs?
The way to reverse an acetal formation.
What is hydrolysis?
The way to make the Hofmann product.
What are bulky bases?
Determines the leaving group's strength.
It determines the reactivity of the carboxylic acid derivative.
What are the resonance states of the carboxylic acid derivatives and the carbonyl carbon's electrophilicity?
It can be subjected to nucleophilic attacks.
What is the less electronegative atom of a double bond?
The conditions where an amine can attack a carbonyl.
What is basic conditions?
The relative position of the leaving group and hydrogen for an E2 reaction.
What is antiperiplanar?
The reason that carboxylic acid can't be converted to amides or esters in basic conditions.
What is the carboxylic acid being converted to a carboxylate?
Two reasons that acetals are good leaving groups.