Enzymes
What does PK do in glycolysis?
Converts PEP to pyruvate and produces ATP
Name 2 metabolic pathways G-6-P is involved in
Glycolysis, glucose production, hexosamine pathway, de novo lipogenesis, glycogen synthesis, pentose phosphate pathway
primarily liver and skeletal muscle
What is the common cofactor between PFK and PK?
Magnesium
Name 1 fate of pyruvate.
1.) Acetyl CoA Production: (Aerobic)
2.) Lactate Fermentation: (Anaerobic)
3.) Ethanol Fermentation: (Anaerobic)
List 2 galactosemia interventions
Eliminate lactose and galactose from diet until type is determined
Calcium/Vitamin D supplementation
In infants:
Eliminate breast milk
Recommend lactose-free formulas (soy, casein hydrolysate, elemental)
Describe the regulation of PFK (inhibition and stimulation)
Stimulated: High levels of ADP & AMP (low energy level); fructose 2,6-bisphosphate (hepatocytes)
Inhibited: High levels of ATP & citrate (high energy level); low pH in muscles (prevent lactic acid buildup)
Why is G-6-P important in the hexosamine pathway?
it produces fructose-6-P
Which enzyme is related to type 2 galactosemia?
Galactokinase (GALK)