Origins
What am I saying?
Meds
Potent Potables (Alcohol)
History
100
Deriving from the Greek word for self
What is autism?
100
"My father sent me here. He drove me in a car. The car is yellow in color. Yellow color looks good on me."
What is flight of ideas?
100
Antidepressant often used for insomnia and poor appetite.
What is mirtazapine/Remeron?
100
On average, the body metabolizes 1 standard drink, or this much of you BAL per hour.
What is 0.015 (g/100nL)?
There are 17 standard drinks in 1/5 of hard alcohol!
100
MAOIs were discovered by accident when patients became "inappropriately happy" during a trial for a substance being tested to treat this.
Researchers Selikoff and Robitzek noticed "a subtle general stimulation ... the patients exhibited renewed vigor and indeed this occasionally served to introduce disciplinary problems."
What is tuberculosis?
It was iproniazid. Isoniazid was also tested.
MAOIs can lift the mood of non-depressed people.
200
From a term meaning a preponderance of black bile
What is melancholic?
200
Q: "What city are you from?"
A: "Well, that's a hard question. I'm from Iowa. I really don't know where my relatives came from, so I don't know if I'm Irish or French."
What is tangentiality?
- Replying to questions in an oblique, tangential or irrelevant manner, losing the original goal.
200
SNRI also FDA approved for neuropathic and MSK pain.
What is duloxetine/Cymbalta?
200
Wernicke encephalopathy's clinical triad.
What are ophthalmoplegia, ataxia, and confusion?
200
In 2018 the FDA granted Breakthrough Therapy Designation for this for treatment-resistant depression and in 2019, the FDA granted Breakthrough Therapy Designation for it to treat major depressive disorder.
What is psilocybin-assisted therapy?
"Breakthrough Therapy designation is a process designed to expedite the development and review of drugs that are intended to treat a serious condition and preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over available therapy on a clinically significant endpoint(s)."
300
From the emotion induced in people by the god of the woods who was woke from a nap.
What is panic?
300
What is your favorite food?
-Hamburgers are the best.
Where do you like to go for fun?
-Hamburgers, hamburgers are the best.
Are you going anywhere this weekend?
Hamburgers.
What is perseveration?
-A repetition of words and phrases that are maintained as inappropriate responses to further questions.
300
Antipsychotic most associated with akathisia.
What is aripiprazole/Abilify?
300
The toxic intermediate product of alcohol metabolism.
What is acetaldehyde?
300
“emotional aspirin.”
What is Miltown?
400
From a Greek meaning badly stretch, or also tone or tension.
What is catatonia?
400
How are you? Are you having a good day?
-I like turtles.
What is a non sequitur?
400
The only commonly used antidepressant that is in FDA pregnancy category B.
What is bupropion/Wellbutrin?
Most others are C. Maprotiline is B.
Paroxetine is D: "Positive evidence of human fetal risk" from reports, etc. . C shows risk in animal studies, B has no animal risk but no human studies. A has adequate and well controlled human studies. X = studies showing risk.
400
Tactile hallucination experienced during alcohol WD.
What is formication?
400
Inadequate, passive-aggressive, asthenic, cyclothymic, and explosive.
What are personality disorders from earlier DSM editions that no longer exist?
500
From a term "denoting the soft body area below the ribs...first used to denote a form of melancholy that was thought to arise from the liver and spleen".
What is hypochondria?
No longer used in the DSM.
It is "illness anxiety disorder".
500
"An example of the latter is the constant introduction at the beginning of practically every other utterance of the word look, which has the force of peremptoriness and condescension toward one’s interlocutor. This annoying habit can be heard with unfailing regularity in the responses of the npr commentator Cokie Roberts on Monday broadcasts of the program “Morning Edition.” The fact that what follows this interjection is a string of commonplaces being paraded as insights does nothing to allay its noisome effect."
What is stilted or pedantic speech?
500
This is an H1 blocking antihistamine, but it also has serotonin receptor blocking activity. Specifically, it acts to block 5-HT1A and 5-HT2A receptors, which are responsible for the symptoms of serotonin syndrome.
What is cyproheptadine/Periactin?
500
A 50-year-old man w/ DM2 and neuropathy, HTN, and EtOH dependence presented with a 25-pound weight gain over 2.5 months, abdominal distention, and lower extremity edema. His abdomen was distended and 1+ peripheral as well as sacral edema was noted. He was tested for alcoholic cirrhosis and edema of unknown origin, and discharged on furosemide 40 mg twice a day and spironolactone 25 mg daily. Three weeks later, the patient returned with worsening edema and abdominal distention, and new-onset dyspnea at rest. He was taking his medications but was still drinking alcohol. His blood alcohol level was 266 mg/dL upon admission. His blood pressure was 117/78 mm Hg, respirations were 20 breaths per minute, and pulse was 110 beats per minute. Jugular venous distention (JVD) of 9 cm and 2+ peripheral edema ascending from his legs to his sacrum were noted. Rales were heard at both lung bases, as was a third heart sound and a 4/6 systolic ejection murmur. His cognition and cerebellar examinations were normal. +lactic acidosis. Wha do you suspect?
Alcohol related wet Beri Beri/heart failure?
Can respond remarkably well to thiamine.
"Wet beriberi is one of the clinical syndromes associated with thiamine deficiency. Thiamine, in its phosphorylated form thiamine pyrophosphate (TPP), is the precursor for the cofactor of both pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, which are both key enzymes of the Krebs cycle. The Krebs cycle is an essential part of aerobic glucose metabolism. A decrease in the activity of these 2 enzymes due to thiamine deficiency may lead to the tissue accumulation of pyruvate and lactate. Moreover, the accumulation of pyruvate and lactate decreases peripheral resistance and increases venous blood flow, increasing the cardiac preload. Increased preload and myocardial dysfunction ultimately leads to congestive heart failure. Wet beriberi mainly triggers right heart failure...moderate pulmonary hypertension is common for wet beriberi patient".
500
A "nonspecific condition" in old editions of the DSM, "This category is for individuals who are not classifiable as anti-social personalities, but who are predatory and follow more or less criminal pursuits, such as racketeers, dishonest gamblers, prostitutes, and dope peddlers."
What is "dyssocial behavior'? From the DSM 2.
(DSM-I classified this condition as "Sociopathic personality disorder, dyssocial type).