Field of Hemes
CD68+, S100+, CD1a+, Langerin+ and is associated with which mutation?
Langerhans cell histiocytosis (LCH)
BRAF V600E mutation seen in 50% of cases
What is the minimum hemoglobin concentration (g/dL) for donor qualification in men and women?
Men 13.0 g/dL
Women 12.5 g/dL
And cannot be higher than 20.0 g/dL
Ki-67 was developed in this city, after which it was named
Kiel, Germany
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What am I? (PowerPoint image)
Coccidioides immitis
This mutated gene is seen in 30% of lung carcinomas and is associated with smoking and mucinous histology
KRAS
The specific subtype of MDS with a particular cytogenetic abnormality conferring a favorable prognosis; what is the cytogenetic abnormality
deletion 5q; isolated or with 1 additional abnormality except 7q deletion
MDS with isolated del(5q)
This blood group antigen is a receptor for Plasmodium vivax. Individuals with a null phenotype are thus resistant to infection by this malaria species.
Duffy (Fy)
FY protein is a receptor for malaria, and individuals may have a mutation in the FYB gene. This results in loss of Duffy expression on RBC's.
This Vanderbilt School of Medicine alum led the landmark study describing the growth requirements and morphologic features of Histoplasma capsulatum in 1934. (Hint: a famous street downtown bears his family name)
William DeMonbreun
I was found in a BAL from a transplant patient. What am I? (PowerPoint image)
Pneumocystis jiroveci
Clusters of small organisms which look like cups, crescents, boats, and crushed ping-pong balls; note the central dark staining dot on GMS; organisms not visible on H&E but see foamy exudate
Gastrointestinal stromal tumors (GIST) typically express a mutation in this gene, but when GIST has epithelioid morphology it often does not.
80% have c-kit activation; epithelioid morphology often has mutation in PDGFRA.
These three cytogenetic abnormalities result in an automatic diagnosis of AML, regardless of blast %
t(8;21), RUNX1T1-AML1
t(15;17), PML-RARα
inv(16), Inversion 16
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What is the donor deferral period for those who have traveled to an area where malaria is endemic but have no symptoms of malaria?
3 months; this was recently changed from 12 months to help increase blood donations
Someone who has lived for at least 5 years in an area where malaria is endemic must wait 3 years to donate (3 years from departure from that area)
The 19th century pathologist who first described and named chordoma in 1846
Rudolf Virchow
I can be seen in CSF, urine, BAL, and pap smears on cytology (PowerPoint image)
Alternaria
Note they are rarely pathogenic and are considered contaminant; brown-pigmented conidia with longitudinal and transverse septations with a pointed end and a blunt end
The most common translocation in this lesion (PowerPoint image)
90% harbor t(12;16), DDIT3-FUS
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This inherited bone marrow failure syndrome is characterized by pure erythroid aplasia in infancy (macrocytic anemia with reticulocytopenia) and various congenital anomalies (bifid or triphalangeal thumbs, hypertelorism, flat nasal bridge).
Diamond-Blackfan syndrome
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Irradiated blood products require what dose of radiation to the center of the product and what dose to any point in the product (units in Gray)
25 Gy at the center
Miniumum of 15 Gy at any point in the product
This former renowned chair of Pathology at Vanderbilt pioneered the chick embryo technique for culturing viruses in 1931, which lead to the development of multiple vaccines
Dr. Ernest William Goodpasture
This infection is found in dolphins and causes a chronic skin infection in humans with a keloidal appearance. What is the infection or the organism? (PowerPoint image)
Lobomycosis, caused by Lacazia loboi
GMS shows budding yeasts forming short chains
The translocation seen in alveolar rhabdomyosarcoma which is associated with an unfavorable prognosis
60% harbor t(2;13), PAX3-FOXO1A, associated with unfavorable prognosis
20% harbor t(1;13), PAX7-FOXO1A, associated with favorable prognosis
20% of ARMS lack a recurring translocation
This is the most frequent chromosome abnormality associated with this leukemia (PowerPoint image)
This is T-cell prolymphocytic leukemia
inv(14), inversion of chromosome 14 in 80% of cases
The most frequently involved alloantigen in neonatal alloimmune thrombocytopenia (NAIT) in the Caucasian population.
Human platelet antigen 1a (HPA-1a)
Rudolf Virchow began his medical internship at this famous Berlin hospital, where he later served as Director for the Institute for Pathology in 1856 (hint: also the name of a Netlflix show)
Charité.
This hospital was established in 1710 in anticipation of the bubonic plague. Subsequently became a charity hospital for the poor and then a teaching hospital in 1828; much of it destroyed during the Battle of Berlin in Spring of '45 and subsequently used as a Red Army hospital. It is now a world-class research and teaching hospital. A Netflix TV series is based on this history.
This disease occurs in tropical areas and is characterized by a chronic infection of the skin and soft tissue; characteristic fungal structures are present on H&E (PowerPoint image)
Chromoblastomycosis, caused by organisms Fonsecaea, Phialophora, Cladophialophora, Cladosporium, and Exophiala
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The translocation seen in this tumor (PowerPoint image)
Extraskeletal Myxoid Chondrosarcoma
t(9;22), NR4A3-EWSR1 in 50-70% of cases