Hand Sanitizer
This was the goal of the Credence Study...
What is:
To assess the effects of treatment canagliflozin on renal outcomes in patients with T2D and albuminuric CKD.
This was one of the Credence baseline characteristics...
What is:
Patients we’re mostly male w/mean age of 63yrs
Additional characteristics were similar between the 2 trmt groups, including: Approx 50% had CVD, Mean glycated hemoglobin of 8.3%, Mean eGFR of 56.2 ml/min/1.73m, Median urinary albumin-to-creatinine ratio equal to 927 mg/g
These are secondary endpoints for Credence...
Composite of CV death or hospitalization for heart failure
Composite of CV death, MI, or stroke
Hospitalization for heart failure
Composite of ESKD, doubling of serum creatinine, or renal death
CV death
Death from any cause
Composite of CV death, MI, stroke, hospitalization for heart failure, or unstable angina
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What is TP
These were the key inclusion criteria for the Credence Study...
What are:
Adults >/= 30 years of age
T2D w/HbA1c of 6.5-12%
Established CKD (eGFR 30-90 ml/min/1.73m of body surface area AND albuminuria… UACR> 300-5000 mg/g
Received a stable dose of an ACEi or ARB for at least 4 weeks prior to randomization
This was the primary efficacy endpoint for Credence...
What is a composite of ESKD (dialysisfor >30 days, kidney transplantation, or eGFR < 15ml/min/1.73m sustained for > 30 days according to lab assessment, doubling of serum creatinine from baseline sustained for > 30 days, or death from renal causes
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What is Chronic Care Cribs
ESKD, doubling of serum creatinine, or death from renal or CV causes...
What is patients in the Canagliflozin group experienced lower rates of these events compared to placebo.
This song release in 1980 by The Police, works as a perfect reminder to maintain 6ft of personal space
What is “Don’t Stand so Close to Me”?
This much anticipated film sequel opening starring Tom Cruise and Val Kilmer (think sand volleyball), has been pushed back to Dec 2020 due to CV.
What is Top Gun Maverick?
These were the primary efficacy outcomes for Credence in the Canagliflozin group and Placebo group...
What is
Canagliflozin: 43.2 events per 1000 patient years
Placebo: 61.2 events per 1000 patient years
(30% lower relative risk (hazard ratio, .7; 95% confidence interval, .59-.82; P=0.00001)
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If you have to make this at home because you cannot find it at the store, the main ingredient is Isopropyl alcohol...
What is hand sanitizer?
Johnson & Johnson first introduced the epidemic mask, made from sterile gauze during this pandemic...
What is the 1918 Spanish Flu?
This event, originally scheduled by Roger Goodell to be held in Las Vegas, proceeded in a virtual format in April.
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The difference in the risk of lower-limb amputation rates observed between the Canagliflozin group and the placebo group...
What is there were no significant differences in this adverse event (HR 1.11;95% CI, 0.79-1.56)
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What is the cyber Kentucky Derby
These are the key exclusion criteria for the Credence Study....
What are:
Suspected non-diabetic kidney disease
Type 1 Diabetes
Prior treatment with immunosuppression for kidney disease
History of dialysis or kidney transplantation
These were secondary efficacy endpoint outcomes in the credence trail...
What is:
CV death/hospitalization for heart failure (HR .69, 95% CI, 0.57-0.83, P<0.001)
CV death, MI, stroke(HR .80, 95% CI, 0.67-0.95, P<0.01)
Hospitalization for heart failure (HR .61, 95% CI, 0.47-0.80, P<0.001)
Composite of ESKD, doubling serum creatinine, or renal death ( HR .66, 95% CI, 0.53-0.81, P<0.001)
There was no significant difference between groups in the 5th secondary endpoint of risk of CV death
The reason the Credence trail concluded early (median follow-up o 2.62 years
What is there was a clear benefit observed for the primary endpoint and the composite of ESKD or death from renal or CV causes