inflammatory
what are the sources of TNF cytokines?
Macrophages; T cells
what are the sources for IL-10?
treg, M, DC
what are the sources for IL-2?
Activated T cells
name all inflammatory cytokines
TNF, IL-1, IL-6, IL-8, IL-17
two noodles flamed my tummy in 1768
what does it mean to activate epithelium?
the tissue and blood vessels are connected, vasodilation causes, leukocytes can enter
what are the sources for IL-1?
M, DC, tissues
what are the sources for IL-4?
Th-2, Mast
what are the sources for G-CSF?
M Endo Stromal
TNF does what?
excess causes what?
activates endothelium
septic shock
IL-17 does what?
-stimulates tissues to recruit neutrophils
-antimicrobial PROTECTS SKIN from bacteria/fungi
what are the sources for IL-6?
Fibroblasts, endothelial, M
what are the sources for TGF-B?
treg, immune cells, tissue cells
what are the sources for GM-CSF?
M Endo Stromal T-cells
IL-1 does what?
promotes epithelium activation
signals infection or injury
IL-10 does what?
stops inflammation
prevents tissues from self damaging
what are the sources for IL-8?
M, epi/endotheial cells
what are the sources for interferons?
type 2:NK/T
name all growth promoting cytokines
IL-2
G-CSF
GM-CSF
Im excited 2 Grow
IL-6 does what?
fever
CRP (hepatic actue phase proteins)
I have FEM boy FEVER so I need CRP.
TGF-B does what?
Treg deveolpment
iGa switching
Fibrosis
what are the sources for IL-17?
th-17
innate lymphocytes
name all regulatory cytokines
IL-4
TGF-B
IL-10
interferons
IL-4 does what?
th-2 development
type 2 immunity activation
IgE switching
IL-8 does what?
chemotaxis gradient formed
activates neutrophils in fungal/ bacterial infection
gr8dient formed
Interferons a/b do what?
y?
A/B=interfere wth viruses, increase MHC 1
Y= activates Mac and cell Mediates immunity