Antibodies
Cutaneous Signs
More Antibodies
Miscellaneous
W/U & Tx
100
What are the antisynthetase antibodies?
Jo-1, PL-7, PL-12 and EJ/OJ
100
Nail capillary changes seen with DM?
Ragged cuiticles
Dilated capillary loops alternating with areas of vessel drop out 
100
Which antibody is associated with calcinosis and contractures in kids (but no increased risk of malignancy)
Anti p140 (NXP2)
100
What percentage of adult onset DM patients have cancer?
25%!
100
What tests should you order if someone with DM has a positive anti MDA5 antibody?
PFTs, DLCO, High Res CT
200
Which antibody is associated with this finding in DM?
Anti Mi-2 (this is flagellate erythema in DM)
200
What is this finding called?
Gottrons Sign (macular erythema overlying joints such as elbows, knees, DIP/PIP and MCP joints)
200
Which autoantibody is associated with necrotic/ulcerative lesions due to cutaneous vasculopathy in DM?
Anti MDA5
200
Wong Type DM is more common in asians and is when clinical features overlap with what other cutaneous disease?
PRP
200
Aside from malignancy, what are other common causes of death in adult DM? (2)
ischemic heart disease
pulmonary complications
300
Which antibodies are associated with Mechanics Hands?
Anti-MDA5 and anti synthestase antibodies (JO-1, PL7/PL12, EJ/OJ)
300
What finding is this?
Calcinosis Cutis
*much more common in JDM (25 to 70%) vs. 20% in adults
favors elbows, knees and buttocks
300
Which autoantibody is associated with cardiac involvement (such as pericarditis, CHF) in DM?
Anti SRP 
300
Most common medications associated with drug induced dermatomyositis?
hydroxyurea (>50%), statins
300
Treatment for calcinosis cutis in DM?
Diltiazem
(can also do surgical excision)
400
Which antibodies are associated with rapidly progressive ILD in DM?
Anti Synthetase antibodies (EJ/OJ, PL7, PL12, Jo-1) * CADM-140 (MDA5)
400
What is this called?
Holster Sign in DM
400
Which autoantibody is associated with classic DM skin findings and good response to treatment?
Anti Mi-2
400
Most common cancers associated with DM?
Ovarian
GI (colon > other)
*nasopharyngeal cancer overrepresnted in asians
others: breast, lung, pancreatic, NHL
400
First line therapies for skin and muscle disease in DM?
Systemic CS, MTX, AZA
500
Which antibodies are associated with classic skin findings WITHOUT clinical muscle disease?
CADM-140 (MDA5) *associated with rapidly progressive ILD
TIF1-y (p155)
500
What finding is pathognomonic for DM?
Gottron's papules
Lichenoid papules overlying knuckles (> other extensor joints)
*less common than gottrons sign
500
Which autoantibody in DM is associated with malignancy, subcutaneous edema and calcinosis in adults?
NXP-2
500
Palmar Papules that are PAINFUL (unlike Gottrons' papules) are associated what what antibodies?
anti CADM-140/MDA5
500
Second line therapy for skin and muscle disease in DM
IVIG
also MMF, cyclosporine, cyclophosphamide, rituximab