Women's Health Initiative
This study was sponsored by this organization
What is the National Heart, Lung, and Blood Institute?
The .5g dosage strength of Divigel provides this dose of estradiol
What is .5mg?
This competitor uses a spray delivery method
What is Evamist?
The ovaries stop producing these two hormones during this stage of life
What is Progesterone and Estrogen?
This was the percent of reduction in frequency of vasomotor symptoms after 12 weeks at the 1 mg dose
What is 87% (nearly 90%)
According to the NAMS updated 2017 Hormone Therapy Position Statement this is the gold standard for the relief of vasomotor symptoms
What is Hormone Therapy?
After applying Divigel the application area should not be washed for at least this amount of time
What is at least an hour?
Estrogens that are administered orally may result in lower bioavailability and require higher doses than non orals due to this
What is Hepatic or first-pass metabolism?
The average age for a woman to experience menopause
What is 51?
This was the amount of days that it took participants to reach a steady state in the Divigel clinical trial
What is 12 days?
More than 2/3 of women enrolled in the WHI Hormone Therapy Trials were this age and older
What is 60 years old?
Application site reactions were seen in this percent of people who used Divigel
What is <1%?
Conjugated estrogens (such as found in Premarin) are a mixture of estrogen compounds and this ingredient
What is pregnant horse urine?
Vasomotor symptoms include these three symptoms
What is hot flashes, chills, and night sweats?
The Divigel clinical trial included this many post- menopausal women in all
What is 488 post menopausal women?
Women who received estrogen plus progestin were at increased risk for this type of cancer
What is invasive breast cancer?
This is the number one adverse reaction reported for Divigel 1 mg
What is metrorrhagia?
This is the only transdermal that does not have an indicated drying time
What is Divigel?
This percent of women in menopause experience hot flashes
What is 50%
At the lowest does Divigel eliminated about this percent of hot flashes in 12 weeks
What is 71%? (nearly 70%)
In women who have a uterus a combination therapy with a progesterone must be used to protect against this
What is Endometrial Neoplasm or cancer?
This is the serum level for Divigel 1 mg
What is 30.5 pg/mL?
This is the lowest dose of estrogen found in patches
What is .025?
Loss of estrogen can also produce these two long term health effects
What is Cardiovascular Disease, and Osteoporosis?
This percent of patients that participated in the study had severe vasomotor symptoms at baseline
What is 98.6%?