PODS
A VUS in genetic testing means this type of mutation has an unclear effect on disease risk.
What is a Variant of Unknown Significance (VUS)?
This class of targeted therapy blocks poly (ADP-ribose) polymerase enzymes involved in DNA repair and is designed with improved selectivity over earlier agents.
What is a next-generation selective PARP inhibitor?
This class of targeted therapy blocks a key cell-cycle checkpoint protein involved in DNA damage repair.
*Bonus points if you can name the trial*
What are CHK1 inhibitors?
2024-0356 Sumitomo SMP-3124 monotherapy CHK1 inhibitor
SAEs are reported in this timeframe
What is within 24 hrs of awareness?
These mutations increase cancer risk by impairing DNA repair pathways in hereditary breast and ovarian cancers
What are BRCA1 and BRCA2 mutations?
AZD9574, DSB2455, EIK1004 were developed with this therapeutic advantage to improve activity against CNS disease.
What is brain penetrance? or What is blood-brain barrier penetration?
This mitotic kinesin motor protein helps align chromosomes during cell division and is being explored as a cancer therapy target.
Hint: HGSOC
What is KIF18A?
Tumor biomarkers are assessed at this frequency
What is baseline and D1 of each cycle?
This type of mutation causes a tumor suppressor gene to lose its normal function, potentially allowing cancer growth.
What is an inactivating mutation?
This class of drug from Gilead was designed to target PARP1 while sparing other PARP family enzymes.
bonus points if you can name what other drug it can be combined with
What is a next generation selective PARP1 inhibitor?
GS-0201
Sacituzumab Govitecan (TRODELVY)
These 2 inhibitors work by blocking a cell-cycle checkpoint kinase, forcing damaged cancer cells into premature mitosis.
Hint: we have 3 trials that have one or both of these inhibitors
What are WEE1 and PKMYT1 inhibitors?
Aprea, Acrivon, DebioPharm
This HER2 status requires ISH/FISH testing to determine correct amplification
What is HER2+
Unlike loss-of-function tumor suppressor alterations, these mutations cause increased protein activity that drives uncontrolled proliferation
What are activating mutations?
These investigational epigenetic therapies target histone acetyltransferases involved in regulating gene expression and tumor growth. Target populations: HER+/HER2Neg BC, TNBC, CRC
What are KAT6/7 inhibitors?
We currently have two trials - 2025-1664 Pfizer KAT 6/7i monotherapy and 2025-1506 BeOne KAT6A/Bi monotherapy or combo w/fulvestrant
Loss of this tumor suppressor pathway can increase dependence on Cyclin-CDK signaling, providing rationale for studying these inhibitors
What is RB1 and Cyclin A/B-RxL inhibitors?
What is patient and witness?
Name the activating mutation in the PI3K pathway
bonus points if you can name the trial.
What is PIK3CA?
2024-1554 Pikavation SNV4818
SNV1521 is being evaluated alongside this HER3-directed antibody-drug conjugate in investigational oncology studies. Can you name two HER3 cancer types?
What are breast, ovarian, colorectal, melanoma, cervical, NSCLC, gastric, pancreatic, H&N?
This inhibitory Notch pathway ligand is highly expressed in many small cell lung cancers and is a target for emerging antibody-drug conjugates.
What is Delta-like ligand 3 (DLL3)?
This is the appropriate party to be a translator
What is Language Assistance?