Drug References
Type of resource that summarizes or interprets original works
What is tertiary literature/resource?
The number of patients needed to receive treatment for one patient to experience a desired outcome
What is number needed to treat (NNT)?
The number of patients who must receive a particular treatment for 1 additional patient to experience a particular adverse outcome
What is number needed to harm (NNH)?
Best quality of evidence based on hierarchy of evidence pyramid
What are systematic reviews and meta-analyses (of RCTs)?
The most common MUE methodology
What is FOCUS-PDCA?
Established inpatient blood glucose goals as 140-180 mg/dL
What is NICE-SUGAR?
Probability that a particular statistical measure of an assumed probability distribution will be greater than or equal to (or less than or equal to in some instances) observed results
What is a p-value?
Risk of an individual having an event given that the patient has not had an event up to a specific point in time
What is a hazard ratio?
Minimum set of recommendations for preparing reports of randomized controlled trials
What is consolidated standards of reporting trials (CONSORT)?
Accrediting body who certifies health care organizations and programs in the United States
What is Joint Commission?
Established norepinephrine as a first line recommended vasopressor in shock
What is the SOAP II trial?
Incorrect rejection of a true null hypothesis
What is a type I error/false positive?
Failure to reject a null hypothesis that is false
What is a type II error/false negative?
The extent to which you can generalize the findings of a study to other situations, people, settings and measures
What is external validity?
Decision-making tool that helps you make the distinction between tasks that are important, not important, urgent, and not urgent
What is Eisenhower-matrix?
A detailed written set of instructions to guide the care of a patient or to assist the practitioner in the performance of a procedure
What is a protocol?
Percentage of patients spared the adverse outcome compared to the control
Measure of association that quantifies ratio of incidence
What is relative risk?
Method used for estimating survival functions from a sample/summarizes the probability of survival over time estimated from a sample
What is a Kaplan-Meier curve?
Thrombocytopenia, timing of platelet count fall, thrombosis, other causes of thrombocytopenia
What is a 4T score?
Debunked the results of the ACURASYS trial for neuromuscular blockade in ARDS
What is the ROSE trial?
Measure of association between exposure and an outcome for retrospective studies
What is odds ratio?
Difference in event rates between two groups, expressed as a proportion of the event rate in the untreated group
What is relative risk reduction?
Research that evaluates effect of intervention on an outcome that patients care about, studies a "common" medical problem where intervention is feasible in given setting, and supplies information that has potential to induce a practice change among clinicians
What is patient-oriented evidence that matters (POEMS)?
Name 3 common pitfalls of conducting a MUE (hint: there are 8!)
Lack of authority, lack of organization, poor communication, poor documentation, lack of involvement, lack of follow-through, evaluation methodology that impedes patient care, lack of readily retrievable data and information