Alzheimer's
These brain immune cells became less activated with exercise, meaning they stopped pruning synapses.
What are microglia?
(True/false) exercise increased the number of surviving neurons
false
Exercise reversed dendritic atrophy through this signaling pathway involving a well-known neurotrophic factor.
What is BDNF?
Persistent increase in synaptic strength following high-frequency stimulation; increased with exercise
What is Long Term Potentiation (LTP)?
This one thing improved in ALL four studies
What is dendritic spine density?
Exercise reduced the AGE/RAGE pathway. Why does that help synapses?
What is AGE/RAGE triggers microglial activation and synapse loss?
Exercise improved functional recovery on these two behavioral tests (name one)
What are grid walking and wire hang?
This surgery on mice removed their ovaries to model menopause.
What is ovariectomy (or OVX)?
What neurotransmitter plays a crucial role in the development of Parkinson's
What is dopamine?
Name one of the three molecules that helps increase BDNF during exercise.
What is osteocalcin, or irisin, or lactate?
This behavioral test showed that exercise improved spatial learning and memory in Alzheimer's mice.
What is the Water Maze?
This measure of brain damage did NOT change with exercise.
What is infarct volume?
These two brain regions are particularly vulnerable to dendritic atrophy following estrogen loss in menopause
What is the prefrontal cortex and hippocampus
The type of aggregates exercise reduced in the substantia nigra
What are α-synuclein aggregates? (lewy bodies)
This is what all four conditions studied today have structurally in common