Path buzzwords
Rosenthal fibers (2)
ON glioma
astrocytoma
CFH and ARMS2
AMD susceptibility genes (50x more likely!)
latanoprost
prostaglandin analog
increase uveoscleral outflow
cytokines secreted by helper T 1 cells (Th1)
IL-2, IL-12, TNF-B, IFN-y
meretoja syndrome
subset of lattice K dystrophy with systemic amyloid
gelsolin gene
homer wright rosettes (2)
Rb
neuroblastoma
VMD2
AKA BEST1
best disease
miotics increase aqueous outflow -- contraction of ciliary muscle opens TM
cytokines secreted by helper T 2 cells (Th2)
IL-4, IL-5, IL-10
alagille syndrome
axenfeld anomaly but with cholestasis, and other systemic signs
Touton giant cells
JXG
TIMP3
sorsby macular dystrophy
betaxolol
BBs reduce aqueous production by...
decreasing cyclic AMP (inhibiting NA/K pump) in ciliary endothelium
cytokine ratio a/w primary intraocular lymphoma
IL10:IL6 ratio greater than 1.0
Laurence-moon syndrome
same spectrum as bardet-biedl
but LMS has spastic paraplegia and NO polydactyly
Psammoma bodies (in ophtho)
ON meningioma
pituitary prolactinoma
OAT
gyrate atrophy
brimonidine
reduce aqueous production by decreasing episcleral venous pressure
heredity patern of coat's disease
nonhereditary proliferative exudative vascular disease
more common in males 10:1
Lofgren, heerfordt, mikulicz
3 specific types of systemic sarcoid. too much to type. look it up.
langhans
sarcoid
(horseshoe shaped ring of nuclei)
CHM
choroideremia
diamox
LHON nucleotide substitution position
11778
G to A change in ND-4 gene
Note: 14484 more likely to show late spontaneous improvement in visual function
bassen-kornzweig syndrome
Abetalipoproteinemia. AR.
Tx: Vitamin A and E