management
This class of drugs is used first to control palpitations and tremor in Graves’ disease.
What are beta-blockers?
This autoimmune disease results in the immune system attacking the thyroid gland, which results in hyperthyroidism and increased metabolism.
What is Graves Disease?
The medications used during pregnancy + graves.
What is:
- propylthiouracil is given in the 1st trimester and methimazole is given in the 2nd and 3rd
- Goal : keep t4 in upper normal range with the lowest does possible
This is the usual duration of antithyroid drug therapy to attempt remission.
What is 12–18 months?
the trigger and process of cortisol secretion
What is:
with stress, the hypothalamus secretes CRH which enters the hypothalamic-hypophyseal portal system and travels to the anterior pituitary gland. This triggers the release of ACTH that results in the release of cortisol from the adrenal gland)
Checking cord blood TRAb levels, do thyroid function tests at days 3-5 and days 10-14 of life.
What is the management of neonatal thyrotoxicosis?
A life-threatening hyperthyroid emergency requiring urgent treatment.
What is Thyroid storm?
The most common causes of Graves Disease
What is genetics and environmental factors (smoking)
The percentage of pregnancies are affected by graves
What is 85%-90%?
This beta-blocker also reduces peripheral conversion of T4 to T3.
What is propylthiouracil (PTU)?
The effects of cortisol on immune system
What is the suppression of proinflammatory cytokines, inflammatory mediators, stabilises membranes of damaged membranes preventing release of proteolytic contents
The labour and delivery managements
What is:
Thyroid storm prevention, pain and stress management, medications?
This iodine preparation is given preoperatively to reduce thyroid vascularity.
What is Lugol’s iodine?
The link between Graves Disease and stress (hint: cortisol drives IL-12 down and IL-4 up)
What is the imbalance of T helper cells?
AB transfer, Medication shift, symptom management
What are the three key considerations of Graves’ Disease and pregnancy?