Sequencing of this oncoprotein gave the initial clues to cell proliferation and transformation.
What is Src protein?
100
The 1st Growth factor discovered that provokes premature eye opening in newborn mice.
What is epidermal grwoth factor?
100
The numbers of spontaneously dimerized receptors is greatly increased before of more frequent collision in the plasma membrane to favor cancerl cell proliferation.
What is the function of EGF-R?
200
An enzyme that appears removes a high energy phosphate group from ATP and transfers it to a suitable protein substrate.
What is protein kinase?
200
This is found to have mitogenic effects when applied to epithelial cells.
What is the epithelial genetic factor?
200
A rat orthology of human HER2/ErbB2 Receptor that has diverse structural alterations causing dimerization of the receptors in the absence of ligand binding to create a potent oncoprotein.
What is Neu?
300
This can phosphorylate multiple, distinct substrate proteins within a cell to be alterted; others can attach phosphate groups to the side chains of serine and threonine.
What are the functions of a protein kinase?
300
Epithelial growth factor is found to be closely related to this oncogene after the discovery of a transforming retrovirus that rapidly induces erythroleukemia.
What is erbB oncogene?
300
These separate polypeptides that associate with cytoplasmic domains of these receptors through covalent links.
What are Jaks?
400
This percent exhibits a rise the percent of total phosphoamino acids after being transformed by cells of the v-src oncogene.
What is 1%?
400
This characteristic is best described in the connection between erbB and EGF-R.
What is ligand independent firing?
400
This receptor immobilizes cell surface proteins, performs juxtacrine signaling, and endocytoses the lingand into the cytoplasm.
What is Notch?
500
These growth factors are involved in tumor pathogenesis/
What are PDGF, EGF?
500
While these two growth factors differ, they both use tyrosine kinases to broadcast signals.
What is a similarity between PDGF and EGF?
500
Undergo "non canonical Wnt signaling" in which alpha separates from its beta and gamma heterodimers.