Coag Cascade
Factors XII, XI, IX, &VIII are all part of this coagulation pathway.
Intrinsic Pathway
This is the most prevalent inherited bleeding disorder.
von Willebrand Disease
The majority of coagulation factors are synthesized by this organ.
The Liver
What is the term for a decreased platelet count (platelet count <150)
Thrombocytopenia
The majority of routine coagulation testing is done with this specimen type.
Sodium citrate, Platelet poor plasma
This test is useful in evaluation of the extrinsic pathway.
PT
This is an inherited disorder of platelet aggregation.
Glanzmann Thrombasthenia
These cells are incorporated into the clot during primary hemostasis and provide structural integrity.
Red Blood Cells
One third of your platelet volume can be found in this organ.
The Spleen
This preanalytic variable will cause a falsely decreased platelet count in a CBC collected in EDTA, but can be mitigated by recollecting in sodium citrate tube.
Platelet Satellitism
This factor is essential for crosslinking fibrin and stabilizing blood clots.
Factor XIII
This disorder caused excessive deposition of platelets in small vessels as the result of decreased ADAMTS-13.
TTP (Thrombotic thrombocytopenic purpura)
This is the primary substance responsible for initiating fibrinolysis.
TPA
You would expect to see these bleeding symptoms in patients with platelet disorders. (5)
Purpura, ecchymoses, epistaxis, menorrhagia, gingival bleeding
This myeloproliferative disorder is characterized by platelet count >1,000 and giant or bizarre shaped platelets.
Essential Thrombocytopenia
This factor is released by damaged endothelial cells and initiates one of the coagulation pathways.
Tissue Factor/Factor III
In this disease, platelets, leukocytes, and endothelial cells are activated by Shiga toxin, resulting in the formation thrombi in small vessels.
HUS (hemolytic uremic syndrome)
These are the storage site for serotonin, ADP, ATP, TXA2 and calcium
Dense granules
In this step of primary hemostasis platelets bind to each other by means of fibrin and GPIIb/IIIa.
Aggregation
This test is used to evaluate whether and abnormal coagulation test is due to a factor deficiency or a circulating inhibitor.
Mixing studies
vWF serves as a carrier protein for this coagulation factor, extending its half-life.
Factor VIII
This disorder is characterized by severe eczema, thrombocytopenia and recurrent infections.
Wiskott-Aldrich syndrome
A deficiency in these proteins is associated with increased risk of thrombosis.
Proteins C & S
This platelet membrane receptor is vital in platelet adhesion.
Glycoprotein Ib
In this thrombocytopenic disorder you will see increased LDH, decreased haptoglobin, and schistocytes on the peripheral smear.
TTP