Gene Mutants
HFE Hemochromatosis
C282Y and H63D
Epclusa
Sofosbuvir + Velpatasvir
Pamela Anderson
HCV
Mononucleosis
EBV
CCA
Increases MASLD/ ALD susceptibility
PNPLA-3
Treatment for Entecavir Resistance
Tenofovir
Ernest Hemingway
Hemochromatosus
Most Severe viral hepatitis
HDV
19 M HBV painful hemorrhagic HCC
Fibrolamellar variant
Lamivudine-resistant HBV
YMDD or
L180M+M204V/I/S
COVID Hepatitis
Remdesivir
Paxlovid
Michael Jackson
Alpha-1 AT Deficiency
Kiss of Death
HSV-2
25 F with fever, weight loss and drenching night sweats
Primary hepatic lymphoma
Progressive Familial Intraheptic Cholestasis Type 3
ABCB4
Approved for HDV Co-Infection
Bulevirtide
Beethoven
HBV/HH/ALD
Outbreaks in Refugee Camps
HEV
Liver Bx: intermediate-grade sarcoma arising from blood vessels in liver
Epithelioid hemangioendothelioma (EHE)
Wilson Disease
ATP7B
Antisense Oligonucleotide for HBV
Bepirovirsen
David Bowie
Liver cancer/ HCC
2020-2021: Fever, SOB, Hypoxemia, ALT=100
COVID/ SARS COV-2
45 F with 3 cm lesion on MRI showing a central stellate scar
Focal nodular hyperplasia (FNH)