Overview of Huntington's
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Your Group gets 100 free points!
If a parent or anyone in your families History has Huntington's Disease what is the chance of you having Huntington' yourself.
If either of your biological parents has Huntington's the chance of you Inheriting the disease yourself is 50% and if your family history has tracing of HD the chance would be lower but entirely plausible.
What is correct term for uncontrollable jerk-like movements stemming from Huntington's disease.
The Correct Medical Term is Chorea
The word Chorea comes is derived from Greek what does it mean?
The word Chorea is one of the most common symptoms of HD meaning "Dance". The reason for this is because of the uncontrollable dance like movements caused in HD.
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Your group loses 200 points!
If the Huntington's Disease gene is partly caused by an Imbalance of a mutated lipids and glucagon in cellular structure how would we stop this Imbalance and further stop cellular decay.
Huntington's Disease happens when there is a mutated gene in the DNA structure of chromosome four it has ABSOLUTELY NOTHING to do with glucagon or Lipids if you said anything other than this you lose 200 points.
What faulty Chromosome does Huntington's Disease Targets and starts from.
Huntington's Disease Targets and Mutates Chromosome 4.
What functions that are usually controlled by the brain are worsened due to Huntington's Disease.
Since HD primarily affects the brain, functions that would normally be controlled by it would worsen and you would gradually lose the ability of them. These functions include planning, organizing, and memory loss.
At what age was George Huntington when he published his famous description of the disease
George Huntington was 22 years old when he published the paper titled "On Chorea"
What was the first widely used drug to cure symptoms of HD
The first widely used and FDA approved drug to cure symptoms of HD was Tetrabenazine.
What is a Neurodegenerative disease? Give a summary of what it is.
Neurodegenerative diseases are incurable, progressive conditions that cause the gradual damage and death of nerve cells (neurons) in the brain and nervous system. Neuro meaning Nerves/neurons and degenerative meaning a process that significantly worsens over time.
Can a person inherit Huntington's disease if neither parent carries the mutation?
Yes A person can inherit Huntington's Disease without Family History of it. This rare variation of the Disease is known as Sporadic Huntington's Disease.
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What is the Gene name in which Huntington's Disease mutates on Chromosome four.
Huntington’s disease (HD) is caused by a mutation in the HTT gene on chromosome 4. The mutation creates a faulty protein that damages brain cells, causing involuntary movements & cognitive decline.
What is the goal in HD physical therapy treatments?
Goals in HD physical therapy treatments typically include combating Movement symptoms like rigidness, Limited movements, and Chorea by improving balance through exercises tailored to the individual making sure the person can stand up properly. Specialized doctors make sure the patient has proper structural support and clean airways to prevent future infections
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Your Group loses 400 points!
What is Sporadic Huntington's Disease, give a quick explanation on why it is different from normal Huntington's Disease
Sporadic Huntington's Disease (HD) is an extremely rare form of Huntington's that occurs in individuals who develop the disease without any family history of it. Normally HD is passed from a Parent who had it, Sporadic HD is unique because the DNA pattern in the Chromosome due to genetic Instability at some point in the Fetus's creation.
What is Chorea? Give a quick summary on what it is.
Chorea is a neurological movement disorder characterized by involuntary, rapid, unpredictable, and purposeless muscle movements that can affect the face, limbs, and torso.
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Your group gets 400 free points!
What are the four drugs I mentioned that can lessen the symptoms of Huntington's Disease
The four drugs I mentioned are Tetrabenazine, Olanzapine, Mood Stabilizers, and Antidepressants
What is the specific three-letter genetic code that repeats excessively in Huntington's Disease? How much times more than a normal person does it repeat.
The three letter genetic code that repeats excessively in HD is CAG in the HTT gene that repeats 20 to 25 times more than that of someone without HD since the normal person has about 17-35 repeats whereas a person with HD has about 40 to 55 (extreme cases being 120).
What genetic phenomenon causes Huntington's disease to sometimes appear at a younger age in successive generations?
The term for the reasoning of Juvenile Huntington's Disease is Genetic Anticipation where the signs and symptoms of an inherited disorder become more severe and appear at an earlier age in each successive generation due to the gene being unstable.
Name every single symptom I have mentioned. (If you miss naming more that five you lose 400 points).
The symptoms I have provided during my presentation are Movement disorders like Chorea, rigidness, limited moving. Losing abilities associated with the brain like planning, organizing, and memory loss you'll even notice a small flicker of irritability that wasn't there before. And finally the long term effects like significant weight loss, Insomnia, losing the ability to walk or talk, and finally death.
In which South American body of water do isolated fishing villages have a Huntington's disease rate roughly 700 times higher than the global average and why is it this way?
The body of water in question is Lake Maracaibo, Venezuela. The reason this specific area has such a Huntington's rate at 700 times higher than the global average is because of shared ancestry to a woman 200 years ago. Further genetic testing proved this.
What is the new cure for Huntington's Disease that alongside other genetic Diseases like Parkinson's and Alzheimer's can cure. EXPLAIN IT.
First of all HD is caused by one faulty and mutated gene in Chromosome four called HTT where the CAG genetic code repeats itself a dangerous amount of times. This mutated gene sends a dangerous message through your neurons that causes an otherwise normal protein to go and destroy your nerve cells and neurons affecting your thinking and movement ultimately fatal. Now in this trial scientists have injecting a harmless virus with rewritten DNA into your brain that tells your neurons to create a new message that destroys the dangerous one. This scientific breakthrough can not only cure Huntington's but also wipe out 75% of symptoms in other diseases, what's more fascinating is one dose of this treatment can last a lifetime!