Type 1 Hypersensitivity
Type 2 Hypersensitivity
Disease examples
Fun facts
100
This antigen type is responsible for type I hypersensitivity.
Soluble antigens
100
This antigen type is responsible for type II hypersensitivity.
Cell-surface antigen
100
Cause of allergic rhinitis and asthma
Type I
100
Immediate phase of type I is caused by degranulation, the late phase is caused by this.
chemokines from mast cells slowly recruit other inflammatory cells (ie. eosinophils) which cause inflammation
200
This reactant binds to the insulting antigen.
IgE
200
This reactant binds to the insulting antigen.
IgG
200
Transfusion reactions and hyperacute allograft rejection
Type II
200
A hypothesis that states our reduced exposure to pathogens due to good sanitation, antibiotic use, and low helminth burden has increased sensitization to benign antigens and thus led to allergies
Hygiene Hypothesis
300
The cell activated by IgE-antigen complex
Mast cell
300
Effector mechanisms (name 1 of the possible mechanisms)
Opsonization leads to phagocytosis (macrophage and neutrophil) and/or complement activation.
NK cell killing by ADCC
300
Rheumatic fever and Goodpasture syndrome
Type II
300
The symptoms related to a type I hypersensitivity allergen depend on this
route of entry
400
Find the mistake: Allergen engulfed by DC --> DC presents allergen on MHC II to Th cell --> Th2 cell activates allergen-specific B cell which releases IgE --> IgE binds MHC II on Mast cell --> antigen binding ab on mast cell causes degranulation of histamine, leukotriene, prostaglandin, etc.
IgE binds FCeR on mast cell
400
An example given in class of cellular dysfunction resulting from a Type II hypersensitivity on a surface receptor.
IgG against FCeR on Mast cells (autoimmune) causes allergic phenotype
400
This hyperthyroid disease is the result of Type II hypersensitivity
Grave's disease
400
Type I hypersensitivity role players such as mast cells seem to be mediators of what type of infection
extracellular parasites
500
Symptoms of mast cell activation
fluid secretion and hypermotility of GI (diarrhea), decreased diameter and increas mucus secretion in airway (wheezing, coughing), increased vascular flow and permeability (edema, erythema, pruritis)
500
This can bind to cell surface and act as antigen complex for Type II hypersensitivity
Drug induced reaction (ie. penicillin)
500
This reaction occurs d/t rapid mast cell degranulation in the presence of a sensitized allergen
Anaphylaxis
500
Daily double!!!!!!! OMG!!!! WOW
Approximately this many genes are related to asthma
100 genes