Cells & Organs
Where B Cells Mature
Bone Marrow
Immunity present at birth
Innate (Natural) Immunity
55-70% WBC Type
Neutrophils
Primary Target Cell
CD4+ T lymphocyte. Rationale: HIV targets CD4+ cells and progressively damages adaptive immunity.
Classic SLE facial Finding
Butterfly (malar) rash. Rationale: An erythematous butterfly rash over the nose and cheeks is a characteristic SLE finding.
Where T Cells Mature
Thymus
Vaccine-created Immunity
Active-Artificial Immunity
WBC Elevated with Allergy/Parasites
Eosinophils
PEP Timing
Within 72 hours. Rationale: PEP is most effective when started promptly and should begin less than 72 hours after exposure.
RA Joint Pattern
Bilateral and symmetric. Rationale: RA typically affects multiple joints bilaterally and symmetrically.
Organ that filters blood and old RBCs
Spleen
Maternal antibodies via placenta/breast milk
Passive-Natural Immunity
WBC initiating Cell-Mediated Immunity
T Lymphocytes
AIDS CD4 Threshold
Less than 200 cells/mm³. Rationale: A CD4 count below 200 is consistent with Stage 3/AIDS.
Gout Crystal Problem
Uric acid crystal deposition. Rationale: Gout results from disrupted purine metabolism with uric acid crystals deposited in joints/tissues
Lymphoid tissue in ileum
Peyer Patches
Transferred through Immune Globulin
Passive-Artificial Immunity
Meaning of left shift in labs
Increase in immature neutrophils/bands
Test used to monitor viral burden
HIV RNA viral load. Rationale: Viral load is used before treatment and serially to monitor progression and response.
Fibromyalgia Hallmark
Chronic widespread musculoskeletal pain with fatigue/sleep disturbance. Rationale: Fibromyalgia is a chronic pain syndrome with tenderness, fatigue and sleep problems.
Airway lymph tissue guarding inhaled microbes
Tonsils and Adenoids
B-Cell Antibody Mediated Immunity
Humoral Immunity
ANC threshold requiring neutropenic precautions
ANC < 1000/mm3
Reason missed ART doses are dangerous
Drug resistance. Rationale: Missing antiretroviral doses can allow viral replication and select resistant virus.
Type 1 Hypersensitivity Emergency
Anaphylaxis. Rationale: Type I immediate hypersensitivity can produce life-threatening anaphylaxis.