autoimmune disorder
The ability of the immune system to distinguish foreign antigen from self
self tolerance
Type I hypersensitivity reactions are mediated by what type of immunoglobulin?
IgE
DiGeorge syndrome is a primary immunodeficiency that is caused by a deletion on what chromosome ?
22
The immunoglobulin that can cross the placenta
IgG
ASO testing is primarily used for
post-streptococcal complications like rheumatic fever or glomerulonephritis
Which autoimmune disease is highly associated with a homogenous ANA pattern and the presence of anti-dsDNA antibody
SLE
Lupus and RA are examples of what type of Hypersensitivity reaction ?
Type III - Immune complex
In DiGeorge syndrome individuals are born with no or very little of what organ?
Thymus
A False negative in serological testing due to antibody excess is called ?
Prozone
Which autoimmune disease is most associated with a nucleolar ANA pattern and anti-RNP antibody ?
MCTD
The Mantoux test ( Tuberculosis skin test) is an example of what type of Hypersensitivity reaction ?
Type IV - Delayed ( T cell )
In DiGeorge Syndrome what major Ion is decreased?
Calcium due to underdeveloped parathyroid gland
Immunoglobulin most abundant in human serum
IgG
The use of particles like latex beads in serological testing is looking for what type of agglutination?
Passive agglutination
Goodpasture's syndrome is caused by autoantibodies to :
basement membrane of glomeruli and alveoli
In Type II hypersensitivity reactions you have antibodies present that can cause either destruction of cells or cell dysfunction . This dysfunction can be increased synthesis as seen in Graves disease or blocking of function as seen in what autoimmune disease ?
MG - Myasthenia gravis
The primary target of HIV is :
CD4 T helper cells
Immunoglobulin most efficient in activating complement
IgM
anti-CCP is associated with what autoimmune disease ?
RA
In a type II and III hypersensitivity you have complement activated. What would you expect the CH50 level to be in these situations?
decreased - when complement is activated you are consuming complement factors - CH50 is a measurement of total complement factors
The confirmatory test for HIV is Western Blot . In order to have a positive Western blot test what must you obtain ? Need specifics
2 out of 3 of the following bands : p24, gp120, gp41
IgE is increased in what 2 main situations
allergy / parasitic infection
an acute phase protein that is used as an indicator of inflammation
CRP