Innate
These innate immune cells can function as "garbage collectors," as an antigen presenting cell, or as a vicious killer depending on its activation level.
What is a macrophage?
This pro-inflammatory cytokine is reliably responsive to acute stress.
What is IL-6?
This immune cell is analogous to that of the cytotoxic T-cell in the adaptive immune system but is considered a part of the innate immune system because it is non specific.
What is a Natural Killer cell?
This pentameric antibody class is the first to be produced in an immune response.
What is IgM
This organ is the primary site where T cell development and maturation occur.
What is The Thymus
These innate immune cells live a short time and can become activated after they leave the blood anywhere in the body.
What are Neutrophils?
Receptors like TLR4 recognize this specific component of Gram-negative bacterial cell walls
What is lipopolysaccharide (LPS)
Another name for a cytotoxic T-cell.
What is a CD8 T-cell?
This B cell is produced after interacting with a T helper cell.
What is a plasma B cell
This specific process ensures that maturing T cells can recognize "self" MHC molecules.
What is Positive Selection
These are the three distinct pathways of complement activation.
What are Alternative, Classical, and Lectin Pathways
A intracellular protein complex that controls cytokine production.
What is NF Kappa B?
Another name for a "helper" T cell.
What is a CD4 T-cell?
This antibody class causes allergies.
What is IgE?
This process eliminates T cells that bind too strongly to self-antigens to prevent autoimmunity.
What is Negative Selection
This protein stabilizes the C3 convertase on the surface of a pathogen.
What is Properdin?
This marker of inflammation is released by liver cells during the induced innate response.
What is CRP?
In the intracellular pathway, this is the specific cellular location where MHC I molecules first meet their antigen partners.
What is the endoplasmic reticulum?
These immune cells are generated during the initial response to T-cell dependent antigens.
What are Memory B-cells?
T cell precursors originate in this location before traveling to the thymus for development.
What is Bone Marrow
These regulatory proteins, like DAF and MCP, prevent complement-mediated damage to host cells.
What are Complement Control Proteins (Regulatory factors)
Describes the movement of neutrophils and macrophages between junctions of endothelial cells
What is diapedesis
This phenomenon leads to affinity maturation by introducing mutations into the BCR after antigen encounter.
What is Somatic Hypermutation
B cells that have never been activated by encountering their cognate antigen.
What is a naive B cell?
These are the two primary anatomical regions of the thymus where different stages of selection occur.
Who is the Cortex and Medulla