Immunology Team
How many languages does the Immunology Team collectively speak?
A. 4
B. 5
C. 6
D. 8
C. 6
What kind of cellular response does an ELISA measure?
A. A-cell
B. B-cell
C. T-cell
D. Monocyte
B. B-cell
What AAV serotype do we use as a vector?
A. AAVrh10
B. AAVrh74
C. AAVrh47
D. MyoAAV
B. AAVrh74
The Immunology Team is studying methods of immune modulation, including a treatment called Imlifidase. What does Imlifidase target to reduce immune response?
A. B-cells
B. T-cells
C. IgG
D. Interferon gamma
C. IgG
Who was the first Immunology Team member, not including management?
A. Ricardo
B. Kevin
C. Wenjing
D. Nick
A. Ricardo
What kind of cellular response does an ELISpot measure?
A. A-cell
B. B-cell
C. T-cell
D. Monocyte
C. T-cell
What age group is Elevidys approved for?
A. 4-5 year olds
B. 6-7 year olds
C. 4-7 year olds
D. All ambulatory patients
A. 4-5 year olds
The Immunology Team is studying potential new vectors to use in the delivery of gene therapy. Which of these is one of those vectors?
A. MyoAAV
B. MicroAAV
C. AAVmDys
D. AAVsrpt
A. MyoAAV
How many samples has the Immunology Team run so far in 2023?
A. 100-500
B. 500-1000
C. 1000-2000
D. >2000
D. >2000
What is the most prevalent antibody isotype present in serum following a dose of gene therapy (long term)?
A. IgG
B. IgM
C. IgA
D. IgE
A. IgG
What is the name of the confirmatory trial for Elevidys?
A. EMBRACE
B. EMBER
C. ENCORE
D. EMBARK
D. EMBARK
The Immunology Team is assisting with studies into the disease Charcot-Marie-Tooth (CMT). What does CMT cause in patients?
A. Tooth decay
B. Cognitive decline
C. Autoimmune disease
D. Nerve degeneration
D. Nerve degeneration
If you stacked up all the ELISA plates the Immunology Team has run in 2023, how tall would they be?
A. 10 feet
B. 20 feet
C. 36 feet
D. 60 feet
D. 60 feet
What is the first antibody isotype present in serum following a dose of gene therapy?
A. IgG
B. IgA
C. IgM
D. IgE
C. IgM
What transgene does Elevidys deliver to patients’ cells?
A. Minidystrophin
B. Dystrophin
C. Microdystrophin
D. Myodystrophin
C. Microdystrophin
The Immunology Team is developing an assay to measure nAb levels. What does nAb stand for?
A. Necrotizing Antibodies
B. Neutralizing Antibodies
C. Natural Killer Antibodies
D. New Antibodies
B. Neutralizing Antibodies
What company competition did the Immunology Team win at the Columbus site earlier this year?
A. Safety Slogan Contest
B. Ping Pong Tournament
C. Let's Go! Competition
D. Chili Cookoff
B. Ping Pong Tournament
Approximately what percentage of DMD patients have pre-existing immunity to our vector?
A. 44%
B. 34%
C. 24%
D. 14%
D. 14%
What is the primary endpoint of our confirmatory trial for Elevidys?
A. Dystrophin expression
B. North Star Ambulatory Assessment
C. Muscle mass
D. Transduction efficiency
B. North Star Ambulatory Assessment
The Immunology Team is developing an ELISA to measure IgM antibodies in serum. What is the structure of IgM?
A. Monomer
B. Dimer
C. Pentamer
D. Double Helix
C. Pentamer