General/Nutritional Anemia
Most common nutritional cause of anemia in children and adolescents.
What is iron deficiency?
This condition is caused by passage of maternal antibodies against fetal RBC antigens.
What is hemolytic disease of the fetus and newborn (HDFN)?
The gamma globin tetramer (1) seen on newborn screen in this condition (2). (2 part answer)
Hemoglobin Bart's in alpha thalassemia.
Hydroxyurea reduces pain crises and acute chest syndrome by increasing this.
What is fetal hemoglobin (Hb F)?
The two antibiotics of choice for a patient admitted with acute chest syndrome.
What are ceftriaxone and azithromycin?
An infant that only drinks goat's milk will likely be deficiency in this vitamin/mineral?
What is folate?
This antibody is the cause of warm autoimmune hemolytic anemia.
What is IgG?
The likely cause of a hemoglobin of 9.5g/dL in a term 12 wo infant.
What is physiologic nadir?
This prophylactic medication dramatically reduced infection related mortality in SCD.
What is penicillin prophylaxis?
The likely etiology of an 8 yr old SCT pt with colicky RUQ pain, hyperbilirubinemia, and vomiting.
What is cholelithiasis?
The two most useful lab values in determining the cause of anemia.
What is MCV and reticulocyte count?
This test looks for red blood cell coated antibodies by adding a anti-IgG reagent.
What is the Direct Coomb's Test?
This test is often used to test for hemolysis but of limited utility in newborns.
What is haptoglobin?
This screening tool should start at age 2 to evaluate stroke risk.
What is transcranial doppler?
The acute management for ischemic stroke in SCD.
What is RBC exchange transfusion?
Increased production of this hormone mediates anemia of inflammation.
What is hepcidin?
Infections associated with cold autoimmune hemolytic anemia.
What is Mycoplasma and EBV?
Most likely diagnosis in a 2 yo M with a recent URI, Hgb 6, MCV 78, retic 0.1%.
What is transient erythroblastopenia of childhood (TEC)?
Structural change in hemoglobin leading to sickle-shaped RBCs.
What is hemoglobin polymerization?
This medication reduces pain crises by inhibiting adhesion of blood cells to P-selectin on endothelial cells.
What is crizanlizumab (Adakveo)?
This formula may help distinguish between iron deficiency anemia and thalassemia.
What is Mentzer Index (=MCV/RBC)?
Diagnostic laboratory result associated with hereditary spherocytosis.
What is increased osmotic fragility?
Most likely diagnosis in a 6 mo M with thumb abnormalities, Hgb 5.4, MCV 97, retic 0.3%.
What is Diamond-Blackfan anemia?
Newborn screen result suggestive of sickle cell trait.
What is FAS?
The most likely infectious cause of a pt with SCD, Hgb 4, retic 0.3%, plt 350K.
What is parvovirus B19?