Symptoms
Pathology
Causes
Treatment
Stuffy Things
100
Cannot remember the past
Retrograde Amnesia
100
Parkinson's
50% substantia nigra death
100
100% Envirnomental
Parkinson's
100
What is the treatment for Huntington's?
NONE!
100
What can cause a lot of genetic diseases?
Stress
200
Starts with Anterograde amnesia, eventually becomes retrograde
Alzheimer's Disease
200
Depression
A gene involved with stress can be overactive and the stress can cause death in the brain
200
100% Genetic
Huntington's
200
Rehab
Korsakoff's Psychosis
200
Describe HMs case
He had a bilateral hippocampectomy, can no longer form new memories, this is how we learned about the function of the hippocampus
300
Disorganized speech, hallucinations, delusions, flat/inappropriate affect
Schizophrenic
300
Huntington's
Errors coded in the cell walls that cause the death throughout the brain, starting in the basal ganglia
300
One part Genetic and one part Stress
Depression, Schizophrenia, Bipolar
300
Why is treating Bipolar hard?
They don't like to be treated because they like the creative manic stages
300
Describe Jeremy's case
He had the blood clot, got anterograde amnesia, he records his entire life
400
Hyperkinesis, hallucinations
Parkinson's patient with too much L-Dopa
400
Alzheimer's
B-Amyloid plaques and dense and diffuse plaques of cell death littered around the brain
400
Alzheimer's
One part genetic and one part due to aging
400
Pallidotomy
You "burn" out some of the palladum, which restores the D1 and D2 pathway. Since the brain continually dies off however, this is not an ideal way for treating Parkinson's
400
Describe Helen's case
She had Alzheimer's
500
Depression is associated with what?
Major Depression, Bipolar, Hypothyroidism
500
Schizophrenia
Fewer cells in the frontal lobe, enlarged ventricles, smaller hippocampus, fewer markers indicating nerve growth, smaller somas, disorganization of cells
500
Anterograde Amnesia
Damage to the telencephalon
500
Describe Alzheimer's Treatment.
Use cholinesterase inhibitors (Cognex) to increase acetylcholine in the brain that will thus increase concentration and focus. Memantine inhibits calcium in the brain and so that stops the progression of the disease.
500
How did the drug addicts get Parkinson's? (Describe the process of the drug itself)
The compound was supposed to be MPPP, but the guy who made it accidentally made MPTP. When injected, it acted like dopamine, stimulating the receptors, and got terminated by reuptake where MOA-B converted it into MPP+, a toxic substance, which destroyed the substantia nigra.
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