This disease effects mostly elderly and only 2.1-12.6 cases per 100,000 of population are diagnosed each year
What is MDS?
100
Fenaux et al " Azacitidine prolongs OS compared with CCR in elderly patients with low Bone Marrow Blast count AML, was published in this journal on this date
What is Journal of Clinical Oncology, Feb 1, 2010
100
This is the 5 year OS for elderly AML patients ( if no treatment)
What is 2%
100
This is the procentage of patients that needed dosing adjustment due to side effects
What is 84%
100
This activity causes 23%of all photocopier problems
What is: sitting on the photocopies and photocopying gtheir own butts
200
This is the number of years after therapy, that most secondary, treatment related MDS cases would occur.
What is 5-7 years
( Alkylating agents, radiation)
( Hodgkin's, non-Hodgekin's, MM, breast, ovarian, testicular)
200
This was the procentage of patients alive at 2 years ( on the Azacitidine arm)
What is 50%
200
This is the procentage of treatment related mortality rate for Intensive Chemotherapy in elderly patients with AML
What is 10-25%
200
This is the recommended dosing schedule for VIDAZA
What is 7days on and 21days off
200
This is the number of husbands that Elizabeth Taylor had throughout her life
What is 7
300
This is the system that helps classify MDS patients to different risk categories
What is IPSS
(international Prognostic Scoring System)
300
This was the median age of patients in this study
What is 70 years of age
-median blast count was 23%
-median number of cycle length was 34 days
-median number of cycles was 8
300
This is the procentage of 2 year OS for AML elderly patients if no treatment
What is 10%
300
This is the recommended minimum length that patients get treated with VIDAZA
What is 6 cycles
300
This animal can live up to 9 days after their head has need cut off
What is Cockroach
400
This cytogenic subgroup has the WORST Prognosis out of all MDS patients ( looking for a specific deletion)
What is 17p Syndrome (loss of short arm)
400
This was the median OS survival in aza patients( months) vs. CCR
What is 24.5 months vs. 14.6 months
400
This is the number (%) of patients that achieved RBC transfusion independence when treated with aza
What is 41% ( vs. 18% RBC)
400
These are the two proposed mechanisms of action fr VIDAZA
What is
1. Hypomethylation
2. Cytotoxicity
400
This is the amount of money that the creator of
Niki Swoosh received for his design
What is $35.00
500
Marie Curie died of this disease that resembles MDS ( It still presents as bone marrow failure and peripheral pencytopenias, however the bone marrow has mainly fat cells and no hematopoietic cells)
What is aplastic anemia
500
These were the 5 secondary end points in Fenaux et al
What is :
1. Morphological CR
2. Transfusion independence
3. Adverse events
4. Rate of fever
5. Hospitalization rates and duration
500
Although this response demostrated low rates, prolonged survival was still achieved
What is Complete Response ( only 18 % CR in AML in elderly, Fenaux 2010)
500
Based on In Vitro data, azacitidine metabolism does not appear to be mediated by this cytochrome
What is P450
( relaxant for drug interactions, induction or inhibition of other drugs is highly unlikely)
500
This is the reason why famale sharks loose their appetite right before they give birth