Disease State
CAPRELSA
COMETRIQ
Adverse Reactions
Potpourri
100
RET stands for
What is rearranged during transfection
100
Dosage of Caprelsa
What is 300 mg qd
100
Name of the phase 3 trial
What is EXAM
100
This adverse reaction occurred most frequently in patients receiving COMETRIQ on the EXAM trial
What is diarrhea
100
Colleague who resides in the state of the current NCAA women's basketball champions
Who is Art DeCillis
200
Two tumor markers followed in MTC
What are CEA and calcitonin
200
Side effects included in the black box warning
What are QT prolongation, Torsades de Pointes and sudden death
200
140 mg, 100 mg and 60 mg
What is the starting dose and dose modifications for COMETRIQ
200
This adverse reaction was the most frequent reason for dose modification
What is PPES
200
Colleagues who have attended a World Cup soccer tournament
Who are Susana and Nancy
300
Familial and sporadic
What are the two forms of MTC
300
The disease control rate (PR+SD) in the phase 3 trial
What is 87%
300
The response rate for patients receiving COMETRIQ enrolled on the EXAM trial
What is 28%
300
According to the Investigator Brochure, this drug is recommended as standard first line therapy for diarrhea
What is Loperamide (Imodium)
300
Colleague who may be co-starring in the next Pirates of the Carribean movie alongside Johnny Depp
Who is Nic Berry
400
MTC accounts for _______% of all thyroid cancers
What is 2%
400
The starting dose of CAPRELSA should be _________ in patients with moderate to severe renal impairment
What is 200 mg
400
The improvement in median PFS between the COMETRIQ and placebo arms in the EXAM trial
What is 7.2 months
400
This drug can be used for patients experiencing anorexia and weight loss
What is Megace
400
Colleague having the most ISTs in their territory
Who is Ali Seyed
500
The proto-oncogene RET is located on chromosome...
What is chromosome 10
500
This percentage of patients required dose reductions for adverse events or QTc prolongation in the phase 3 trial
What is 35%
500
Increased levels of thyroid stimulating hormone (TSH) were observed in ________ of patients receiving COMETRIQ after the first dose
What is 57%
500
CYP3A4 inducers will __________ single-dose plasma cabozantinib exposure.
What is decrease
500
Colleague who might visit the castle called "The White Heron" on one of their vacations
Who is Kevin
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