IgM/IgG
Of which immunoglobulin class are "naturally occurring" antibodies?
What is IgM.
The most common Lewis blood group phenotype.
What is Le(a-b+).
Lack of red cell antigens from this blood group system provide some protection against certain forms of malaria caused by the malarial parasites Plasmodium knowlesi and Plasmodium vivax
What is the Duffy (Fy) blood group system.
Antibodies from this blood group system are mainly IgM, tend to react better at a pH of 6.5, and frequently show dosage.
What is anti-M.
Antibodies that resemble this somewhat rare IgM antibody may be found among dialysis patients with renal failure treated with formaldehyde sterilized instruments.
What is anti-N.
IgG antibodies react best at what temperature?
What is 370C.
The three genes that the Lewis system depend upon to produce the Lewis antigen structures.
What are H, Se (secretor), and Le (Lewis).
This cold reacting antibody is frequently found among patients with Mycoplasma pneumoniae:
What is autoanti-I.
Chronic Granulomatous disease is associated with this blood group system:
What is the Kell system.
Anti-M, anti-N, anti-P1, anti-Le(a), anti-Le(b), and anti-Lu(a) antibodies are almost always of this immunoglobulin class?
What is IgM.
What test is best for detecting IgG antibodies in an individuals serum?
What is the indirect antiglobulin test (IAT)
Individuals with the phenotype Le(a-b+) are always-(secretors or nonsecretors)?
What are secretors because they carry all 3 genes necessary for expression of Le(b) antigen. If any of the 3 genes are expressed in the amorphic form (le, ss, hh), production of Le(b) cannot occur.
Antigens of this blood group system are involved with urea transport.
What is the Kidd (Jk) blood group system.
This cold reacting antibody is frequently found among patients with Infectious mononucleosis and lymphoproliferative diseases.
What is anti-i.
The phenotype S-s- is necessary to form this IgG antibody in Blacks.
What is anti-U.
IgM antibodies are best detected at what temperature?
What is room temperature or colder.
Why can't the Bombay phenotype express the Le(b) antigen?
What is: because Bombay individuals lack the H gene.
This autoantibody is associated with paroxysmal cold hemoglobinurea.
What is autoanti-P (aka as the Donath-Landsteiner antibody)
Glycophorin B encodes which antigens from the MNS system?
What are S, s, and U.
Name antigens (6) whose expression may diminished or abolished with proteolytic enzyme treatment of their red cells.
What is Fy(a), Fy(b), M, N, S, and Xg(a).
IgG antibodies are generally formed in response to what stimuli?
What is transfusion and pregnancy.
Individuals who do not expresses the Lewis gene, will always phenotype as:
What is Le(a-b-).
Antibodies from this system disappear rapidly after their formation and are frequently associated with delayed hemolytic transfusion reactions
What is the Kidd (Jk) blood group system.
Most common Duffy phenotype among Blacks.
What is Fy(a-b-).
This high frequency antigen is antithetical to the Kell (K1) antigen.
What is k, cellano, (K2) antigen.