Random
When the blood vessel is damaged what happens to the flow of blood around the injury? What is the name of the Procoagulant that causes this? Where does it come from?
Vasoconstriction occurs reducing the amount of blood able to escape from the injury, Thromboxane A2, Platelets
What are the three groups of couagulation factors?
Fibrinogen, Prothrombin, Contact
What is the goal of primary hemostasis? Secondary Hemostasis?
Primary: Primary Platelet Plug
Secondary: Stable Fibrin clot
What factor is required to make the stable fibrin clot in the common pathway?
Factor XIII
What is a cofactor? Give an example of one?
Bind to stabalize their enzyem
High Molecular Weight Kininogen(HMWK), Tissue Factor, V, VIII
What is exposed in the subendothelium when a blood vessel is injured? What does it bind to?
Collagen, platelet receptor GP 1a/IIa and GPVI
What does thrombin activate?
Fibrinogen to Fibrin
XIII--->XIIIa
VIII--->VIIIa
V--->Va
What are the names for FI, FII, FIII, FIV
FI: Fibrinogen
FII: Prothrombin
FIII: Tissue Factor
FIV: Calcium
What are the factors for each of the three pathways in order?
Intrinsic: Kallikrein, FXII(Pre-kallikrein), FXI, FIX, FVIII
Extrinsic: Tissue factor, VII
Common: X, V, Prothrombin, thrombin, fibrinogen, fibrin, fibrin monomer, fibrin polymer, XIII
What is factor Xa an example of?
Serine Protease
What is released when vascular injury occurs that begins the Extrinsic coagulation cascade?
Tissue Factor
Which factors are consumed during coagulation?
(Fibrinogen Group) I, V, VIII, XIII
What factors are required to activate Kallikrein?
Pre-kallikrein, HMWK, and XIIa
What is the process that breaks down the stable clot produced by secondary hemostasis?
Fibrinolysis
List the factors of the extrinsic tenase complex and their classification.
VIIa is the vitamin k dependent factor
Tissue factor is the cofactor
Where is von Willebrand Factor (vWF) stored and what does it bind to?
Stored in alpha granules of platelets and Weibel-Palade bodies in the endothelium, binds to platelet receptor GP Ib/IX/V
What is factor V an example of?
Where does the coagulation cascade occur?
On the platelet surface (glycolax)
List the factors and their classifications for the intrinsic tenase.
IXa is the vitamin k dependent factor
VIIIa is the cofactor
What are the factors in the contact group and what pathway are they part of?
XI, XII, Prekallikrein, and HMWK
Intrinsic Pathway
List and describe the 3 phases of platelet activation?
Platelte Adhesion- Collagen exposed platelts bind to vWF and collagen
Platelet Aggregation- fibronectin binds adjacent plts results in PPP (Primary Plt Plug)
Platelet Secretion- Release of granule contents
What do all the tenase complexes have in common?
What is the first factor in the common pathway?
X--->Xa
Which factors are dependent of Vitamin K?
(Prothrombin Group) II, VII, IX, and X
What is the primary substrate of the coagulation cascade? Where is it stored?
Fibrinogen, alpha granules of platelets