Oncology 1
What is the role of mesna?
Given with Ifosphomide as a prophylaxis for hemorrhagic cystitis
Bonus: Brand for ifosphomide?
Boxed warning for SERMS? (ex:tamoxifen)
Increased risk of uterine or endometrial cancer, increased risk of thromoembolic events, and QT prolongation
Inicial dosing for warfarin in a healthy outpatient? (and what population of people would get a lower does and what would that does be?)
Healthy outpatients: 10 mg daily for 2 days, then adjust INR
Bonus: list two brand names for warfarin
Double bonus: How would you explain the briding process with warfarin and enoxaparin (aka when do you stop warfarin?)
Alginic acid and polacrillin potassium are what type of exipients?
Disintegrants
Contraindications for using a Fibrinolytic such as alteplase?
active internal bleeding
HISTORY OF RECENT STROKE
any prior ICH
SEVERE UNCONTROLLED HYPERTENSIONBonus: list another fibrinolytic (brand and generic)
What is the difference (and similarity) between Zinecard and Totect?
Both are Dexrazozoxane but Zinecard is used as a phrophylaxsis for cardiomyopathy and Totect is treatment for extravasation.
What drug is the best to give for a person who is taking tamoxifen but is experiencing the common side effects of hot flashes and night sweats?
Venlafaxine
Antidote for Apixaban and Rivaroxaban? Brand and Generic
andexanet alpha (Andexxa)
What is the beyond use date for a non sterile water containing oral formulation?
14 days when refrigerated
Contraindication for the thiazolidinediones?
NYHA class III/IV heart failure bc of increased fluid
Also a BBW for exacerbaing HF and rosiglitazone has BBW for increased risk of MI
What are Neupogen and Neulasta use for? What are their respective generic names and what are some differences between the two medications?
Used for Neutropenia (they are colony stimulating factors).
Neupogen is Filgrastim (given daily) and Neulasta is Pegfilgrastim (given once per chemo cycle)
Leuprolide and Goserlin are medications in which class?
Gonadotropin releasing hormones (GnRH) agonists.
Bonus: Must be given with what other drug?
Bonus: Brand names?
When starting amiodarone on a patient who is taking warfarin, what do you expect to happen to warfarin levels and what does adjustments should be made?
Warfain levels will be elevated so the does of warfarin should be decreased by 30-50%
What is the beyond use date for a sterile product that required 4 ingredients to make? (at room temp, fridge temp, and freezer temp)
Room temp: 30 hours
Fridge temp: 9 days
Freezer temp:45 days
Generic for Qsymia?
Phentermine and Topiramate ER
REMS program?
What is the max dose (and reason) for the following drugs:
Vincristine; Doxorubicin, Cisplatin, Bleomycin
Vincristine: single dose "caped" at 2mg bc of neuropathy
-Doxorubicin: Lifetime cumulative dose 450-550mg/m2 bc of cardiotoxicity
-Cisplatin: dose per cycle not to exceed 100mg/m2 bs of nephrotoxicity
Bonus: What are the brands for the above meditations?
Cisplatin works where in the cell cycle?
Trick question: It is cell cycle independent
What is the black box warning for Enoxaparin?
Patients recieving neuraxial anesthesia (epidural, spinal) or undergoing spinal puncture are at risk of hematomas and subsuquent paraysis.
ISO level in the PEC?
5
50mg of cortisone is equivalent to how much prednisone?
10 mg
Acute chemo inducede nausea happens ___ hours after chemo and should be treated with which class of medications?
24 hours, 5HT3-RA
examples: ondansetron, Granisetron, dolasetron, and palonosetron
Bleomycin is known for not having which toxicity?
It is NOT myelosuppresive
For Unfactionated Heparin, what is the dose for treatment of a VTE?
80 units/kg IV bolus; 18 units/kg/hr infusion
Bonus: IBW, TBW, or ABW?
Double bonus: Same question but for treatment of ACS/STEMI
(pg 528)
ISO level in the SEC
7
Hepatotoxicity and QT prolongation