Osteosarcoma
Chemo phrases
Causes
tumor biology
Diagnostics
100
3 breeds predisposed to developing osteosarcoma
What are Rottweilers, Irish Wolfhounds, St. Bernards, Great Danes, Dobermans
100
"Splats Cats"
What is cisplatin?
100
This enveloped retrovirus causes several hemopoetic neoplasias in cats
What is feline leukemia virus?
100
These are the stages of the cell cycle.
What are G1, S phase, G2, M phase, Go (arrest)?
100
This stain helps recognize nucleolar organizer regions and can help prognostically indicate canine lymphoma and mast cell tumors.
What is silver stain?
200
Treatment of choice for osteosarcoma
What is amputation followed by chemotherapy?
200
"Red Death"
What is doxorubicin/adriamycin?
200
This contagious virus causes multiple wart-like growths in the oral cavity, labial margins, tongue, hard palate and epiglottis in young dogs.
What is canine papiloma virus?
200
This trasncription regulator protein becomes phosphorylated as a result of DNA damage and arrests cell cycle.
What is p53?
200
This staining procedure uses antibodies to identify cellular and extracellular molecules.
What is IHC (immunohistochemistry)?
300
Predominant locations of osteosarcoma
What are proximal humerus, distal radius, proximal tibia, distal femur ("away from the elbow, towards the knee")
300
"Blue Wimpy" or "Blue Thunder"
What is mitoxantrone?
300
This cause of squamous cell carcinoma in cattle, cats, and humans has a documented dose-response relationship.
What is exposure to UV light/sunlight?
300
These are 2 molecular mechanisms which allow for development of neoplasias.
What are self-sufficient growth, insensitivity to anti-growth signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, tissue invasion or metastasis?
300
This analytic procedure sorts cells using a focused laser and can be used to evaluate tumors for type and cell cycle phase
What is flow cytometry?
400
Prognosis with amputation alone
What is poor- median survival is 4.5 mos.
400
F%^ks up cats
What is 5-FU?
400
This inhalant causes mesiothelioma in people and a similar relationship has been found in dogs belonging to people in an occupation or hobby that is exposed to this substance.
What is asbestos?
400
This is expanded by the production of telomerase by tumor cells
What is telomere maintenance (lack of attrition of telomeres)?
400
This DNA amplification technique can be used to identify a clonal population vs. a multiclonal population as well as immunophenotype of lymphocytes.
What is PCR/PARR?
500
2 negative prognostic indicators
What are elevated alkaline phosphatase and lymph node metastasis?
500
"No pet should be dead without...."
What is pred?
500
This androgen-dependant tumor type is seen more commonly in male intact dogs or in female dogs with a testosterone secreting adrenal tumor.
What is perianal adenoma?
500
Expression this factor and its receptor by tumor cells not only activates endothelial cells for angiogenesis, but is correlated with negative outcome.
What is VEGF and/or VEGF-R?
500
This techinique sections tissue blocks in 1 um slices and evaluates intracellular structures such as basal lamina or granules; it can be used to determine carincomas from lymphoma, or melanomas, mast cell tumors and neuroendocrine tumors.
What is electron microscopy?
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