Orexin Origins
The alternate name for “orexin” which denotes the origin of orexinergic neurons in the brain.
What is hypocretin?
The mechanism of action of TCS-OX2-29, the drug used in Sarah’s first year project.
What is orexin-2 receptor antagonism?
Orexin-2 receptor dysfunction is critically linked to the pathology of this disorder.
What is narcolepsy?
These are the signal durations for our task.
What are 500, 100, and 25 milliseconds?
The other species of animal Eden has worked with (besides rats) during undergrad.
What are pigeons?
The word "orexin" comes from the Greek word “orexis,” meaning this.
What is appetite?
The mechanism of action of SB-334867, the drug used in Reema’s current experiment.
What is orexin-1 receptor antagonism?
The name of the dual orexin receptor antagonist in Eden’s current experiment that is also being explored for treating chronic insomnia, anxiety, and depression.
What is MK-6096/filorexant?
This is the term used to describe when a rat presses the appropriate lever during a non-signal trial.
What is correct rejection?
Besides psychology, Sarah also majored in this subject during undergrad.
What is German?
This is the year that the orexinergic system was discovered.
What is 1998?
The name of the NMDA receptor antagonist that Eden is currently using and will continue to use in her dissertation to produce schizophrenia-like symptoms.
What is MK-801/dizocilpine?
In an article assigned in an earlier lab meeting, ____ administration of orexin-A was more effective than ____ administration in alleviating sleep deprivation-linked cognitive deficits
What are intranasal and intravenous administration?
After drug infusions, rats are placed in a modified version of the task wherein the attentional demands are increased by introducing this disorienting element.
What is a flashing house light/visual distracter?
When Eden was 19, she hastily got a tattoo of this neurotransmitter on her shoulder because she was feeling impulsive.
What is serotonin?
Orexins are known to facilitate these psychological processes (name 3).
What are wakefulness/alertness, food-seeking, water-seeking, drug-seeking, reward learning and memory, fear learning and memory, general attention/learning/memory, etc. There are so many!
This is a potential concern when administering orexin receptor antagonists in our attention task.
What is demotivation (fatigue is also acceptable)?
Aside from schizophrenia, Alzheimer’s, and sleep-related illnesses, name one other psychiatric disorder that may be treated by enhancing orexinergic neurotransmission.
What are ADHD, depression, anorexia, Parkinson’s, and many others?
This is the name of the version of the task where the rats first learn to associate lever pressing with water rewards.
What is shapeh2o?
Sarah worked with this animal model of disordered eating in her undergraduate research.
What is binge-type eating?
Orexin neurons innervate this brain area, which is the primary source of brain-wide acetylcholine and is necessary for attentional processing.
What is the basal forebrain?
Sarah’s master’s thesis involves emulating the cognitive deficits of Alzheimer’s disease by using 192 IgG-saporin to lesion the neurons projecting from the ___ to the ___.
What are the neurons projecting from the basal forebrain to the prefrontal cortex?
Many orexinergic drugs in our lab can only be infused intracranially and not systemically due to their inability to do this.
What is cross the blood brain barrier?
We use this as a measure of motivation or fatigue in the task.
What are omissions?
Eden and Sarah went to this state last summer to present at the International Behavioral Neuroscience Society conference and had an absolute blast (we were at a resort!).
What is Florida?