It's All Relevant
What are the "three" different names of medications?
What is chemical, generic, and trade/brand?
What types of drugs does it apply to?
What are oral meds?
What are the 4 parts of pharmacokinetics?
ADME
A- Absorption
D- Distribution
M- Metabolism
E- Excretion
What is the trade/brand name?
What normal people know it as.
What are the 2 processes solid drugs must go through to be absorbed?
What is dissolution and disintegration?
How are drugs absorbed?
- Transdermal
- Mucus membranes
- Gi tract lining
- Respiratory tract
What are the 3 primary ways to cross a cell membrane?
- Channels or pores (very small ions)
- Aid of transport system (ex: P-glycoprotein)
- Direct penetration (most common, only for lipid-soluble drugs)
What determines the rate of absorption?
Rate of dissolution
Describe the differences between enteral and parenteral administration.
Enteral:
- Via GI tract
- Common routes: oral or PO
-feeding tubes (ex: gastric tubes)
- Slower absorption
Parenteral
- Usually referred to as "by injection"
- Common routes: IV, SQ, IM
- faster absorption
What does P-glycoprotein do?
Transports drugs OUT of cells
-Pumps drugs out of the cells in the kidney into the urine
- Pumps drugs out of the cells in the brain into the bloodstream
Do powders or solid tablets dissolve more quickly?
Powders
What affects absorption?
- Blood flow
- Digestive enzymes & motility
Where is P-glycoprotein present?
Liver, kidneys, placenta, intestine and capillaries of the brain