Intro to Med Chem
Name two sciences linked by medicinal chemistry.
Organic chemistry, pharmacology, biochemistry, biology, medicine
The greater the TI, the ____ the drug.
The greater the TI, the SAFER the drug
Which process of identifying the lead compound is more sufficient?
Drug design
Drug discovery
1. Drug design
How will a drug react if it interacts with an enzyme?
It will act as an inhibitor/slow down the reaction.
The interference of pharmaceutical drugs with biological processes IS DEFINED as…
Side effects
What is the placebo effect?
The actual therapeutic effect achieved by a placebo
What are the 2 ways to express effectiveness and safety?
Therapeutic index, therapeutic window
Why is it important to look for the lead compound or NCE?
It assures activity toward the biological target.
What are cell receptors?
Communicators between the cell and the space around it.
True or False- the intramuscular injection produces the fastest therapeutic effect
False- the intravenous injection produces the fastest therapeutic effect
Why is a double-blind test incorporated in a clinical trial?
To reduce the possibility of a conscious or subconscious bias in the interpretation of the experimental results.
Drug Bioavailability: which injection method is assigned a drug bioavailability of 100%
intravenous injection
What happens in the Clinical trials? Hint: 2 main things
1) Drug info is sent to the authorities
2) Drug is tested on humans.
What type of bonds can a drug and cell receptor form?
Dipole-Dipole, hydrogen, and ionic bonds.
What are withdrawal symptoms? List 3.
Attempting to quit drugs after being addicted.
1.Nausea
2.Vomiting
3.Muscle cramps