Various Topics
This describes a disease or condition that has no known cause.
What is idiopathic?
This percentage of patients diagnosed with CML are asymptomatic.
What is 50%?
This laboratory test uses fluorescent probes to detect specific DNA sequences, such as BCR-ABL.
What is FISH?
This medication is a first-line tyrosine kinase inhibitor used to treat CML.
What is Imatinib?
A very young, immature blood cells produced in the bone marrow.
What is a blast?
This describes what the body does to a drug, including absorption, distribution, metabolism, and excretion.
What is pharmacokinetics?
This physical exam finding occurs when abnormal blood cell production expands the spleen.
What is splenomegaly?
This bone marrow test evaluates cellularity, maturation, and abnormal cell populations.
What is a Bone Marrow Biopsy?
This is the specific enzyme activity inhibited by imatinib.
What is BCR-ABL tyrosine kinase activity?
A type of white blood cell that helps your body fight parasitic infections, manage allergic reactions, and control inflammation.
What is an eosinophil?
This describes when a piece of a chromosome transfers to another without “reciprocation” by a segment from the other chromosome.
What is nonreciprocal translocation?
This medical condition describes why fatigue is a symptom of CML.
This laboratory test is used to track progress and effectiveness of Imatinib by measuring transcription of a specific gene.
What is RT-PCR?
This term describes the process by which a cancer cell undergoes genetic changes and adapts to avoid its death via a treatment.
What is resistance?
Blood cells made in the bone marrow that give rise to neutrophils, eosinophils, basophils, monocytes, red cells, and platelets.
What is a myeloid cell?
This CBC abnormality describes an increased number of circulating white blood cells.
What is leukocytosis?
This protein produced by the Philadelphia chromosome causes uncontrolled proliferation by acting as a continuously active enzyme.
What is BCR-ABL tyrosine kinase?
This shows us the spectrum of maturation within the myeloid cells.
What is a peripheral blood smear?
Dasatinib is how many times more potent than regular Imatinib.
What is 325 times more active?
Immature white blood cells normally found only in the bone marrow identified by a distinctive kidney bean-shaped (indented) nucleus and secondary granules.
What is a promyelocyte?
A CBC provides a quantitative assessment of these three blood cell lines.
What are red blood cells (erythrocytes), white blood cells (leukocytes), and platelets (thrombocytes)?
This process describes blood cell production occurring outside the bone marrow, commonly in the spleen during CML.
What is extramedeullary hematopoesis?
A bone marrow biopsy shows us if the cells are mature, well formed, and in expected numbers and is quantified using this ratio.
What is Myeloid:Erythroid or M:E ratio?
This second-generation tyrosine kinase inhibitor blocks BCR-ABL and Src family kinases and can be used when resistance develops.
What is Dasatinib?
A bone marrow sample that contains significantly more cells than normal for a person's age, with an overabundance of myeloid series cells.
What is hypercellular marrow with myeloid predominance?