1
what is the nickname for Propofol?
What are two very common side effects of propofol?
-Drowsiness and dizziness
What brain chemical linked to reward can propofol increase?
Dopamine
What can misuse of propofol lead to legally?
-criminal and malpractice cases
Why can propofol misuse become compulsive?
-effects on the brains reward system
What type of drug is propofol?
An intravenous anesthetic
What dangerous breathing-related effect can propofol cause?
-Respiratory suppression
What feeling can low doses of propofol cause?
-Euphoria, dizziness, or feeling drunk/elated - loss of mental and physical ability
-Why is propofol considered dangerous without monitoring?
-It can suppress breathing and heart function quickly
What spinal cord receptors are linked to reduced pain signals with propofol?
-glycine receptors
What neurotransmitter does propofol mainly affect?
GABA
What cardiovascular effect can propofol cause?
-Hypotension (low blood pressure)
Why is propofol misuse more common among anesthesia providers?
-easier access to it
What is most dangerously affected during overdose?
-respiratory system- respiratory suppression
What kind of breathing problems may occur with propofol?
-weak or shallow breathing
How fast can propofol sedate someone?
In less than 30 seconds
What might someone feel around the IV site during injection?
-Burning or stinging
Is propofol federally scheduled as a controlled substance?
No
What is propofol used for?
-moderate sedation to general anesthesia
What can happen to heart rate?
It may become too fast or too slow
How long does a clinical effect from induction usually last?
about 10 minutes
What syndrome can develop from long term propofol use?
-Propofol infusion syndrome
What are common triggers for propofol misuse?
-Anxiety, insomnia, stress, followed by craving driven compulsive use
What does propofol do to the brain's activity level?
-calm or suppresses brain activity
What is the most notable case of Propofol misuse?
-Micheal Jackson's death.