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A 16-year-old adolescent is brought to the emergency department for unsteadiness and stumbling while walking, which was first noticed 4 days ago. She has a history of cystic fibrosis and is non-compliant with follow up and medications. On examination, she appears thin and malnourished. She has an ataxic gait and diminished deep tendon reflexes in the lower extremities, as well as some generalized weakness in the lower extremities. Which vitamin deficiency is responsible for her symptoms?
What is Vitamin E… CF patients have difficulty absorbing the fat-soluble vitamins [ADEK].
Vitamin E deficiency manifests as generalized weakness, decreased deep tendon reflexes, hemolytic anemia, visual changes, and ataxia.
Vitamin A deficiency is associated with blindness, defective tooth enamel, decreased growth, and a decreased immune response.
Vitamin D deficiency results in a wide array of clinical presentations, including seizures and tetany (due to hypocalcemia), failure to thrive, hypotonia, widened cranial sutures, bony changes, developmental delay, delayed tooth eruption, and bowed legs.