KNOW IT
This general term refers to the preparative treatment given to the patient prior to transplant.
What is conditioning?
This preservative for frozen cellular products can cause acute reactions when reinfused into the patient.
What is DMSO (dimethylsulfoxide)?
The term used to describe the divided doses of Total Body Irradiation.
What are “Fractions”?
This chemotherapy drug can cause severe mucositis and has short stability.
What is Melphalan?
3 of the several criteria used to determine patient eligibility for a transplant.
What are: age, physical condition, comorbidity score, diagnosis and disease stage, previous treatment(s), insurance, caregiver support, psychological state, donor suitability and availability?
The term used to describe the process of expanding stem cells and pushing them into the peripheral circulation.
What is Mobilization?
This important aspect of care reduces the incidence of mucositis, especially with TBI.
What is frequent oral care?
This high level immune activation can occur in a Haplo SCT or CAR-T patient.
What is a CRS (Cytokine Release Syndrome)?
This chemotherapy drug, used also as an immunosuppressant, may cause hemorrhagic cystitis, fluid retention, and SIADH.
What is Cyclophosphamide?
These are important steps in being ready for a cellular infusion (name 4).
What are: recent vital sings/pre-assessment, PICC flow by gravity, pre-meds given, product release, MD name/#, handoff on other patients?
The term used to describe removing of antibodies of some recipients to reduce their risk of graft rejection.
What is a Desensitization?
These are the three most common organs affected by Acute Graft Versus Host Disease.
What are the skin, liver, and GI tract?
This is a term used when a patient's blood counts have recovered to a safe level.
What is "Engraftment"?
The therapeutic trough level of Tacrolimus
What is 5 - 10 ng/mL?
Three important aspects of patient care prior to a patient leaving for TBI.
What are: giving pre-meds, documentation recent VS, having patient use the bathroom (and giving PRN meds if needed)?
The cell surface marker that is used to determine the number of stem cells in a donated stem cell product.
What is CD34+?
This is what happens if the stem cell product does not reconstitute the patient's hematopoietic system.
What is graft failure?
The condition in which T cells attack the Allo patient as engraftment occurs.
What is Graft Versus Host Disease?
This chemotherapy is used for SCT conditioning and for lymphodepletion prior to CAR-T infusion
What is Fludarabine?
This organ problem may be the result of conditioning and presents with weight gain, abdominal distension, and increased bilirubin
What is Sinusoidal Obstruction Syndrome (SOS) or Veno-Occlusive Disease (VOD) of the liver?
The cluster of genes that determines the 'match' between donor and recipient.
What is the Human Leukocyte Antigen (HLA) system?
An inflammatory condition that occurs after transplant in which there is a rapid increase in neutrophils plus fever, rash, and capillary leak/weight gain.
What is engraftment syndrome?
This life-threatening infection can lead to bowel perforation and death and warrants frequent abdominal assessments.
What is neutropenic enterocolitis (typhlitis)?
This immune suppressant can cause multiple organ toxicities, including seizures.
What is Tacrolimus?
This latent virus is often reactivated in the Allo patient, either from him/herself or from the donor.
What is Cytomegalovirus (CMV)?