Genes
This is the inheritance pattern for Sickle Cell Disease
What is Autosomal Recessive
The normal shape of a RBC
What is a Biconcave Disc
This term describes a blockage of blood vessels which can be caused by things like abnormally shaped cells.
What is Vaso-Occlusion
This demographic is most affected by Sickle Cell Disease
What is (who are) Black and African Americans
You palpate your patient's T8 vertebra (after gaining consent and doing a proper inspection, of course). Your right thumb is more posterior, but becomes more even when the patient flexes. On the whiteboard, write down the proper nomenclature for your diagnosis and which of Fryette's laws it follows.
What is T8 F Rr Sr
What is Type II
The type of mutation seen in Sickle Cell Disease
What is a Point/ Missense Mutation on the Beta Gene
This cellular struture, made up of spectrin, becomes less stable as the RBC sickles. Eventually it collapses and the cell remains sickled.
What is the Cytoskeleton
This phenomenon occurs due to sickled cells getting trapped in this organ OR this organ attempting to produce more RBCs to compensate for those lost
What is Splenomegaly
The lifespan of a sickled cell
What is 10-20 Days
During mitosis, a cell divides improperly. The resulting cell, along with its progeny, are all missing one X chromosome. This results in a life-long genetic condition producing symptoms such as a low hairline and low-set or unusually shaped ears. (Be specific in your answer)
What is Mosaic Turner Syndrome
The chromosome affected in Sickle Cell Disease
What is Chromosome 11
This term describes the process of the abnormal Hb in RBCs clumping together during a deoxygenated state.
What is Polymerization
Your and your friend have decided to go for a run. One mile in, your friend tells you they have Sickle Cell Trait. They ask if they should be worried about their condition.
What is... Generally, no. However, under extreme stress, potentially yes.
(I didn't have a better way to word this answer lol)This treatment is designed to trigger the production of HbF, preventing the RBC from sickling
What is Hydroxyurea
You are looking at a histology slide and notice a particular type of tissue. This tissue is striated, has a higher ratio of cytoplasm than nucleus, and has intercalated discs.
What is Cardiac Tissue
The amino acid change that occurs in HbSS
What is Glutamic Acid to Valine
This word describes the process that renders this organ non-functional.
Due to lack of function of this organ, patients with Sickle Cell Disease are more prone to infection with this type of organism.
(There are two answers for this question)
What is Autosplenectomy
What is (are) Encapsulated Bacteria
The acute condition, commonly associated with Sickle Cell Anemia, that may explain why our patient had:
- Fever and tachycardia
-Low SpO2
- Used accessory muscles to breathe
What is Acute Chest Syndrome
During an acute crisis, packed RBCs are used. These are some reasons why (name at least 1/4 of the listed answers).
What is (are):
- Diluting HbS
- Correcting severe, acute anemia
- Preventing strokes
- Resolving Acute Chest Syndrome
A patient presents with inability to retract the scapula and rotate the scapula inferiorly. The physician determines that the issue is due to an injured nerve, but is trying to recall which nerve it is.
What is the Dorsal Scapular Nerve
This describes the change in amino acid charge found in HbSC
What is Negative to Positive
(Glu --> Lys)
In HbSC, dysfunctional K-Cl cotransporters force potassium out of the RBC. This outward flood of ions leads to a distinct consequence affecting the state of the cell and blood.
What is Cellular Dehydration OR Blood Hyperviscosity
HbSC presents with milder features, but still puts patients at high risk of several clinically unique and significant symptoms (name at least 1/4 of the listed answers).
What is:
- Retinopathy
- Asceptic Bone Necrosis
- Priapism
- Late-Onset Splenic Sequestration or Enlargement
You are rotating in a hospital and you notice that your patient with Sickle Cell Disease has a normal MCHC. Your attending physican asks you to explain to why this value is normal.
What is Structural- Not Manufacturing Shortage- of Hb
Joseph is thinking about his favorite protein, AS160. Due to his his intense love for AS160, he has forgotten the previous protein that phosphorylates it. (Help him so he can stop stressing about it.)
What is AKT